Novel and selective inhibitors of KRASG12D

被引:0
|
作者
Bhavar, Prashant Kashinath [1 ]
Surampudi, Uday Kumar [1 ]
Sarma, Partha Pratim [2 ]
Shidore, Mahesh Mohan [2 ]
Kshirsagar, Anuj Ramesh [3 ]
机构
[1] VRise Therapeut Inc, Cambridge, MA USA
[2] VeGen Therapeut Pvt Ltd, Hyderabad, Telangana, India
[3] VeGen Therapeut Inc, Hyderabad, Telangana, India
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2681
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Inhibition of KrasG12D with a novel small molecule inhibitor alters the pancreatic cancer microenvironment
    Kemp, Samantha B.
    Cheng, Noah
    Markosyan, Nune
    Sor, Rina
    Kim, Il-Kyu
    Hallin, Jill
    Shoush, Jason
    Quinones, Liz
    Brown, Natalie
    Bassett, Jared B.
    Joshi, Nikhil
    Yuan, Salina
    Smith, Molly
    Vostrejs, William P.
    Perez-Vale, Kia Z.
    Kahn, Benjamin
    Mo, Feiyan
    Donahue, Timothy R.
    Radu, Caius G.
    Clendenin, Cynthia
    Christensen, James G.
    Vonderheide, Robert H.
    Stanger, Ben Z.
    MOLECULAR CANCER RESEARCH, 2023, 21 (05)
  • [22] Preclinical studies of TSN1611, a potent, selective, and orally bioavailable KRASG12D inhibitor
    Shang, Erchang
    Zhong, Boyu
    Zhang, Tony
    Dong, Chunlan
    Ma, Shengtang
    Yang, Anjiang
    Jia, Ziyang
    Zheng, Renjuan
    Li, Jing
    Fu, Han
    Lai, Liangbao
    CANCER RESEARCH, 2024, 84 (06)
  • [23] ATDC and KrasG12D Cooperate to Promote Pancreatic Adenocarcinoma in Mice
    Wang, L.
    Wilkinson, J. E.
    Yang, H.
    Wu, J.
    Di Magliano, M. Pasca
    Simeone, D. M.
    PANCREAS, 2010, 39 (08) : 1355 - 1355
  • [24] KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma
    Grimont, Adrien
    Zhao, Zhen
    Leach, Steven D.
    Chandwani, Rohit
    CANCER RESEARCH, 2019, 79 (24)
  • [25] Activation of oncogenic KrasG12D induces oral tumor formation
    Caulin, C
    Lang, GA
    Lozano, G
    Roop, DR
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (03) : A24 - A24
  • [26] Myocardial KRASG12D expression does not cause cardiomyopathy in mice
    Dalin, Martin G.
    Zou, Zhiyuan
    Scharin-Tang, Margareta
    Safari, Roghaiyeh
    Karlsson, Christin
    Bergo, Martin O.
    CARDIOVASCULAR RESEARCH, 2014, 101 (02) : 229 - 235
  • [27] The Tumorigenic Roles of Mutant KrasG12D Isoforms in Pancreatic Cancer
    Chen, J.
    Haddock, A.
    Gui, F.
    Wan, J.
    Zhu, X.
    Bi, Y.
    Ji, B.
    PANCREAS, 2018, 47 (10) : 1379 - 1379
  • [28] Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy
    Issahaku, Abdul Rashid
    Mukelabai, Namutula
    Agoni, Clement
    Rudrapal, Mithun
    Aldosari, Sahar M.
    Almalki, Sami G.
    Khan, Johra
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [29] Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation
    Fan, Heng-Yu
    Shimada, Masayuki
    Liu, Zhilin
    Cahill, Nicola
    Noma, Noritaka
    Wu, Yun
    Gossen, Jan
    Richards, JoAnne S.
    DEVELOPMENT, 2008, 135 (12): : 2127 - 2137
  • [30] Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy
    Abdul Rashid Issahaku
    Namutula Mukelabai
    Clement Agoni
    Mithun Rudrapal
    Sahar M. Aldosari
    Sami G. Almalki
    Johra Khan
    Scientific Reports, 12