Indium(III) iodide-mediated Strecker reaction in water:: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

被引：85
|
作者：
Shen, Zhi-Liang [1 ,2 ]
Ji, Shun Jun [1 ]
Loh, Teck-Peng [2 ]
机构：
[1] Suzhou Soochow Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
TETRAHEDRON | 2008年 / 64卷 / 35期
基金：
中国国家自然科学基金;
关键词：
Strecker reaction; alpha-aminonitrile; indium(III) iodide; water; three-component reaction;
D O I：
10.1016/j.tet.2008.06.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, efficient and environmentally friendly method has been developed for the synthesis of alpha-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields. (C) 2008 Published by Elsevier Ltd.
引用
收藏
页码：8159 / 8163
页数：5
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