Visualization of UV-induced damage on single DNA molecules

被引：26
|
作者：
Lee, Jinyong [1 ,2 ]
Park, Hyun Seung [1 ,2 ]
Lim, Sangyong [3 ]
Jo, Kyubong [1 ,2 ]
机构：
[1] Sogang Univ, Dept Chem, Seoul 121742, South Korea
[2] Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South Korea
[3] Korea Atom Energy Res Inst, Res Div Biotechnol, Jeongeup 580185, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 42期
基金：
新加坡国家研究基金会;
关键词：
ATOMIC-FORCE MICROSCOPY; RESOLUTION; SYSTEM; GENE;
D O I：
10.1039/c3cc38884k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ultraviolet radiation induced DNA damage such as double stranded breaks and single stranded breaks is visualized at the level of single DNA molecules. Molecular observations provide a map of DNA radiation-mediated breakages, revealing the sequence dependency of DNA damage rather than random occurrences.
引用
收藏
页码：4740 / 4742
页数：3
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