UV-induced strand break damage in single stranded bromodeoxyuridine-containing DNA oligonucleotides

被引：14
|
作者：
Doddridge, ZA
Warner, JL
Cullis, PM [1 ]
Jones, GDD
机构：
[1] Univ Leicester, Ctr Mechanisms Human Tox, Leicester LE1 7RH, Leics, England
[2] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England
来源：
CHEMICAL COMMUNICATIONS | 1998年 / 18期
关键词：
D O I：
10.1039/a804416c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aerobic UVB photolysis of single stranded bromodeoxyuridine (BrdU)-containing DNA oligonucleotides produces immediate and latent strand break products consistent with a specific BrdU base radical-mediated abstraction of the C1' hydrogen atom from the 5' neighbouring deoxyribose.
引用
收藏
页码：1997 / 1998
页数：2
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