Recent advances in optogenetics and pharmacogenetics

被引:66
|
作者
Aston-Jones, Gary [1 ]
Deisseroth, Karl [2 ,3 ]
机构
[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA
关键词
Optogenetics; Pharmacogenetics; Channelrhodopsin; DREADD; Designer receptor; Viral transduction; Neurotransmitter signaling; Motivation/cognition; Autonomic function; Sensory function; Translational neuroscience; PROTEIN; FAMILY;
D O I
10.1016/j.brainres.2013.01.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Optogenetics with microbial opsin genes, and pharmacogenetics with designer receptors, represent potent and versatile experimental modalities that can be integrated with each other as well as with a rich diversity of synergistic methods to provide fundamental opportunities in neuroscience research. The 7th Annual Brain Research Meeting in New Orleans in October 2012, Optogenetics and Pharmacogenetics in Neuronal Function and Dysfunction, brought together leading researchers that have developed and used these tools to explore a wide range of questions in nervous system function and dysfunction. This special issue of Brain Research includes articles by speakers in this meeting and others, which together synthesize and summarize the state of the art for optogenetics and designer receptors. This article is part of a Special Issue entitled Optogenetics (7th BRES) (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 5
页数:5
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