Recent advances in optogenetics and pharmacogenetics

被引:66
|
作者
Aston-Jones, Gary [1 ]
Deisseroth, Karl [2 ,3 ]
机构
[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA
关键词
Optogenetics; Pharmacogenetics; Channelrhodopsin; DREADD; Designer receptor; Viral transduction; Neurotransmitter signaling; Motivation/cognition; Autonomic function; Sensory function; Translational neuroscience; PROTEIN; FAMILY;
D O I
10.1016/j.brainres.2013.01.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Optogenetics with microbial opsin genes, and pharmacogenetics with designer receptors, represent potent and versatile experimental modalities that can be integrated with each other as well as with a rich diversity of synergistic methods to provide fundamental opportunities in neuroscience research. The 7th Annual Brain Research Meeting in New Orleans in October 2012, Optogenetics and Pharmacogenetics in Neuronal Function and Dysfunction, brought together leading researchers that have developed and used these tools to explore a wide range of questions in nervous system function and dysfunction. This special issue of Brain Research includes articles by speakers in this meeting and others, which together synthesize and summarize the state of the art for optogenetics and designer receptors. This article is part of a Special Issue entitled Optogenetics (7th BRES) (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 50 条
  • [21] Recent advances in optogenetics: Report for the session 12 at the 19th International Conference on Retinal Proteins
    Kataoka, Mikio
    Terakita, Akihisa
    BIOPHYSICS AND PHYSICOBIOLOGY, 2023, 20
  • [22] Editorial on Special Issue "The Advances and Applications of Optogenetics"
    Govorunova, Elena G.
    Sineshchekov, Oleg A.
    APPLIED SCIENCES-BASEL, 2020, 10 (18):
  • [23] Advances and challenges in hereditary cancer pharmacogenetics
    Cascorbi, Ingolf
    Werk, Anneke Nina
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2017, 13 (01) : 73 - 82
  • [24] Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
    Soong, R
    Diasio, RB
    PHARMACOGENOMICS, 2005, 6 (08) : 835 - 847
  • [25] Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy ininflammatory bowel disease
    Moon, W.
    Loftus, E. V., Jr.
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2016, 43 (08) : 863 - 883
  • [26] Advances in Optogenetics Applications for Central Nervous System Injuries
    Geng, Yuanming
    Li, Zhenxing
    Zhu, Junhao
    Du, Chaonan
    Yuan, Feng
    Cai, Xiangming
    Ali, Alleyar
    Yang, Jin
    Tang, Chao
    Cong, Zixiang
    Ma, Chiyuan
    JOURNAL OF NEUROTRAUMA, 2023, 40 (13-14) : 1297 - 1316
  • [27] Recent advances - Recent advances in rehabilitation
    Wade, DT
    de Jong, BA
    BMJ-BRITISH MEDICAL JOURNAL, 2000, 320 (7246): : 1385 - 1388
  • [28] An overview of the recent progress in irinotecan pharmacogenetics
    Fujiwara, Yutaka
    Minami, Hironobu
    PHARMACOGENOMICS, 2010, 11 (03) : 391 - 406
  • [29] RECENT PROGRESS AND CHALLENGES IN PSYCHIATRIC PHARMACOGENETICS
    Greenbaum, Lior
    Lerer, Bernard
    ISRAEL JOURNAL OF PSYCHIATRY AND RELATED SCIENCES, 2012, 49 (01): : 33 - 34
  • [30] Advances in drug metabolism and pharmacogenetics research in Australia
    Mackenzie, Peter I.
    Somogyi, Andrew A.
    Miners, John O.
    PHARMACOLOGICAL RESEARCH, 2017, 116 : 7 - 19