Bayesian Matching of Unlabeled Point Sets Using Procrustes and Configuration Models

被引:10
|
作者
Kenobi, Kim [1 ]
Dryden, Ian L. [2 ]
机构
[1] Univ Nottingham, Sch Biosci, Nottingham NG7 2RD, Leics, England
[2] Univ S Carolina, Dept Stat, Columbia, SC 29208 USA
来源
BAYESIAN ANALYSIS | 2012年 / 7卷 / 03期
基金
美国国家科学基金会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
Gibbs; Markov chain Monte Carlo; Metropolis-Hastings; molecule; protein; Procrustes; size; shape; ALIGNMENT; SHAPE;
D O I
10.1214/12-BA718
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
The problem of matching unlabeled point sets using Bayesian inference is considered. Two recently proposed models for the likelihood are compared, based on the Procrustes size-and-shape and the full configuration. Bayesian inference is carried out for matching point sets using Markov chain Monte Carlo simulation. An improvement to the existing Procrustes algorithm is proposed which improves convergence rates, using occasional large jumps in the burn-in period. The Procrustes and configuration methods are compared in a simulation study and using real data,where it is of interest to estimate the strengths of matches between protein binding sites. The performance of both methods is generally quite similar, and a connection between the two models is made using a Laplace approximation.
引用
收藏
页码:547 / 565
页数:19
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