Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages

被引：1

作者：

Krutetskaya, Z. I. ^{[1
]}

Milenina, L. S. ^{[1
]}

Naumova, A. A. ^{[1
]}

Butov, S. N. ^{[1
]}

Antonov, V. G. ^{[1
]}

Nozdrachev, A. D. ^{[1
]}

机构：

[1] St Petersburg State Univ, Univ Skaya Nab 7-9, St Petersburg 199034, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 471卷 / 01期

关键词：

ENTRY;

D O I：

10.1134/S1607672916060041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-beta-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest that intact rafts are necessary for signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

引用

页码：390 / 392

页数：3

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