Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages

被引：1
|
作者：
Krutetskaya, Z. I. [1 ]
Milenina, L. S. [1 ]
Naumova, A. A. [1 ]
Butov, S. N. [1 ]
Antonov, V. G. [1 ]
Nozdrachev, A. D. [1 ]
机构：
[1] St Petersburg State Univ, Univ Skaya Nab 7-9, St Petersburg 199034, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 471卷 / 01期
关键词：
ENTRY;
D O I：
10.1134/S1607672916060041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-beta-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest that intact rafts are necessary for signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.
引用
收藏
页码：390 / 392
页数：3
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