Structural, enzyme inhibition, antibacterial and DNA protection studies of organotin(IV) derivatives of thiophene-2-carboxylic acid

被引：29
|
作者：
Abbas, Saghir [1 ]
Hussain, Mukhtiar [1 ]
Ali, Saqib [1 ]
Parvez, Masood [2 ]
Raza, Ahsan [3 ]
Haider, Ali [1 ,4 ]
Iqbal, Jamshed [3 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
[3] COMSATS Inst Informat Technol, Dept Pharmaceut Sci, Abbottabad 22060, Pakistan
[4] Jacob Univ, Sch Sci & Engn, D-28725 Bremen, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 724卷
关键词：
Thiophene-2-carboxylic acid; Organotin(IV); Spectroscopy; X-ray crystallography; Biological screening; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; COMPLEXES; CHEMISTRY; CLEAVAGE; AGENTS;
D O I：
10.1016/j.jorganchem.2012.11.033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of five monomeric and polymeric complexes: [Bu3Sn(C5H4O2S)] (1), [Me3Sn(C5H4O2S)] (2), [Cy3Sn(C5H4O2S)] (3), [Bu2Sn(C5H4O2S)(2)] (4), [Oct(2)Sn(C5H4O2S)(2)] (5) of thiophene-2-carboxylic acid have been synthesized by the reaction of ligand acid with di- organotin compounds for the complexes 4, 5 and its sodium salt with tri-organotin compounds for the complexes 1, 2 and 3 respectively, in suitable stoichiometries. All complexes have been structurally characterized by vibrational and magnetic resonance (H-1, C-13 NMR) spectroscopies. The structures of complexes (2), (3) and (4) have also been elucidated by X-ray crystallography. Relative potential has been assessed for their anti-bacterial, DNA protection and inhibitory assay against acetyl cholinesterase and butyryl cholinesterase. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：255 / 261
页数：7
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