Structural, enzyme inhibition, antibacterial and DNA protection studies of organotin(IV) derivatives of thiophene-2-carboxylic acid

被引：29
|
作者：
Abbas, Saghir [1 ]
Hussain, Mukhtiar [1 ]
Ali, Saqib [1 ]
Parvez, Masood [2 ]
Raza, Ahsan [3 ]
Haider, Ali [1 ,4 ]
Iqbal, Jamshed [3 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
[3] COMSATS Inst Informat Technol, Dept Pharmaceut Sci, Abbottabad 22060, Pakistan
[4] Jacob Univ, Sch Sci & Engn, D-28725 Bremen, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 724卷
关键词：
Thiophene-2-carboxylic acid; Organotin(IV); Spectroscopy; X-ray crystallography; Biological screening; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; COMPLEXES; CHEMISTRY; CLEAVAGE; AGENTS;
D O I：
10.1016/j.jorganchem.2012.11.033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of five monomeric and polymeric complexes: [Bu3Sn(C5H4O2S)] (1), [Me3Sn(C5H4O2S)] (2), [Cy3Sn(C5H4O2S)] (3), [Bu2Sn(C5H4O2S)(2)] (4), [Oct(2)Sn(C5H4O2S)(2)] (5) of thiophene-2-carboxylic acid have been synthesized by the reaction of ligand acid with di- organotin compounds for the complexes 4, 5 and its sodium salt with tri-organotin compounds for the complexes 1, 2 and 3 respectively, in suitable stoichiometries. All complexes have been structurally characterized by vibrational and magnetic resonance (H-1, C-13 NMR) spectroscopies. The structures of complexes (2), (3) and (4) have also been elucidated by X-ray crystallography. Relative potential has been assessed for their anti-bacterial, DNA protection and inhibitory assay against acetyl cholinesterase and butyryl cholinesterase. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：255 / 261
页数：7
相关论文
共 50 条
  • [31] Spectroscopic studies of biologically active organotin(IV) derivatives of 2-[N-(2,4,6-tribromophenylamido]propanoic acid
    K. Shahid
    S. Shahzadi
    S. Ali
    Journal of the Iranian Chemical Society, 2008, 5 : 579 - 587
  • [32] Spectroscopic Studies of Biologically Active Organotin(IV) Derivatives of 2-[N-(2,4,6-Tribromophenylamido]propanoic Acid
    Shahid, K.
    Shahzadi, S.
    Ali, S.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2008, 5 (04) : 579 - 587
  • [33] Determination of antioxidant, DNA protection, enzyme inhibition potential and molecular docking studies of a biomarker ursolic acid in Nepeta species
    Yenigun, Semiha
    Basar, Yunus
    Ipek, Yasar
    Behcet, Lutfi
    Ozen, Tevfik
    Demirtas, Ibrahim
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 42 (11): : 5799 - 5816
  • [34] STRUCTURAL CHEMISTRY OF ORGANOTIN CARBOXYLATES .12. SYNTHESIS AND CHARACTERIZATION OF DIORGANOTIN(IV) CARBOXYLATES CONTAINING 2-THIOPHENE-CARBOXYLIC OR 2-FURAN-CARBOXYLIC ACID - CRYSTAL-STRUCTURE OF [ET2SN(O2CC4H3S)2]
    VATSA, C
    JAIN, VK
    KESAVADAS, T
    TIEKINK, ERT
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1991, 410 (02) : 135 - 142
  • [35] Synthesis, spectroscopic studies and antileishmanial, antibacterial, antifungal, cytotoxicity and insecticidal activities of organotin(IV) derivatives of (E)-4-oxo-4-(2,4,6-trichloroanilino)-2-butenoic acid
    Shahzadi, S
    Shahid, K
    Ali, S
    Malik, A
    Ahmed, E
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2005, 27 (05): : 541 - 547
  • [36] Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies
    Rasool, Nasir
    Ikram, Hafiz Mansoor
    Rashid, Ammara
    Afzal, Nazia
    Hashmi, Muhammad Ali
    Khan, Muhammad Naeem
    Khan, Ayesha
    Imran, Imran
    Rahman, Hafiz Muhammad Abdur
    Shah, Syed Adnan Ali
    TURKISH JOURNAL OF CHEMISTRY, 2020, 44 (05) : 1410 - 1422
  • [37] Synthesis, structural elucidation, and biological activity to organotin(IV) derivatives of (E)-2,3-bis(4-chlorophenyl)-2-propenoic acid
    Sadiq-ur-Rehman
    Choudhary, Muhammad Aziz
    Ahmad, Zahoor
    Mirza, M. Aslam
    Ali, Saqib
    HETEROATOM CHEMISTRY, 2017, 28 (05)
  • [38] Preliminary in vitro Cytotoxic Assay on HepG2 and Antibacterial Screening Activity: Synthesis and Characterization of Organotin(IV) Complexes Derivatives of 2-Methyl-3-nitrobenzoic Acid
    Win, Yip-Foo
    Teoh, Siang-Guan
    Ha, Sie-Tiong
    Tengku-Muhammad, Tengku-Sifzizul
    Yousif, Emad
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (06) : 3376 - 3380
  • [39] Synthesis and biological evaluation of novel active arylidene derivatives of 5,6-dihydro-4H-cyclopenta[b]- and 4,5,6,7-tetrahydrobenzo[b]-thiophene-2-carboxylic acid
    Kathiravan, P. R.
    Venugopal, M.
    Muthukumaran, S.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (04) : 2315 - 2331
  • [40] Synthesis and biological evaluation of novel active arylidene derivatives of 5,6-dihydro-4H-cyclopenta[b]- and 4,5,6,7-tetrahydrobenzo[b]-thiophene-2-carboxylic acid
    P. R. Kathiravan
    M. Venugopal
    S. Muthukumaran
    Research on Chemical Intermediates, 2017, 43 : 2315 - 2331
12345