Antibodies to anthrax protective antigen can neutralize as well as enhance the anthrax lethal toxin action

被引：0
|
作者：
Shemyakin, I [1 ]
Dubiley, S
机构：
[1] State Res Ctr Appl Microbiol, Obolensk, Moscow, Russia
[2] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia
来源：
Multidisciplinarity for Parasites, Vectors and Parasitic Diseases, Vol 1 | 2004年
关键词：
D O I：
暂无
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Next generation of anti-anthrax vaccine must be based on well-defined component(s) eliciting easily assessed protective immune response. It is widely accepted that the anthrax protective antigen (PA) would be the key component of such a vaccine. At the same time, recent studies indicate that the immune response to the PA is complex, and additional research is needed to prepare safe and efficient PA-based vaccine prototype. In the present communication we discuss recently reported phenomenon of the antibody mediated enhancement of lethal toxin action.
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页码：17 / 21
页数：5
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