Antibodies to anthrax protective antigen can neutralize as well as enhance the anthrax lethal toxin action

被引：0

作者：

Shemyakin, I ^{[1
]}

Dubiley, S

机构：

[1] State Res Ctr Appl Microbiol, Obolensk, Moscow, Russia

[2] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

来源：

Multidisciplinarity for Parasites, Vectors and Parasitic Diseases, Vol 1 | 2004年

关键词：

D O I：

暂无

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Next generation of anti-anthrax vaccine must be based on well-defined component(s) eliciting easily assessed protective immune response. It is widely accepted that the anthrax protective antigen (PA) would be the key component of such a vaccine. At the same time, recent studies indicate that the immune response to the PA is complex, and additional research is needed to prepare safe and efficient PA-based vaccine prototype. In the present communication we discuss recently reported phenomenon of the antibody mediated enhancement of lethal toxin action.

引用

页码：17 / 21

页数：5

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