Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors

被引：18
|
作者：
Chen, Hua [1 ]
Yang, Tianyu [1 ]
Wei, Sinan [1 ]
Zhang, Hongzhi [1 ]
Li, Rui [1 ]
Qin, Zhanbin [1 ]
Li, Xiaoliu [1 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Bicyclic azasugar; Thiazolidin-4-one; HIV-RT inhibitor; Pummerer rearrangement; PUMMERER REACTION; INDOLIZIDINES;
D O I：
10.1016/j.bmcl.2012.09.100
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7041 / 7044
页数：4
相关论文
共 50 条
  • [41] Novel 2-phenyl-3-(Pyridin-2-yl) thiazolidin-4-one derivatives as potent inhibitors for proliferation of osteosarcoma cells in vitro and in vivo
    Deng, Yaqi
    Pi, Rou
    Niu, Li
    Zhao, Yun
    Ni, Dan
    Song, Longlong
    Li, Zi
    Han, Wangyujing
    Wei, Qinghua
    Han, Yuqiao
    Zhu, Tong
    Luo, Zhengli
    Sun, Donghui
    Dong, Suzhen
    Liu, Shunying
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 228
  • [42] Novel fluorinated thiazolidin-4-one derivatives: synthesis and anti-cancer potential against HepG2 and HCT116 cell lines
    Kadam, Shreyash D.
    Mammen, Denni
    Zunjar, Vishwanath
    Bagul, Rahul R.
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2024, 77 (09)
  • [43] An efficient One-pot three-component synthesis, Molecular docking, ADME and DFT predictions of new series Thiazolidin-4-one derivatives bearing a Sulfonamide moiety as potential Antimicrobial and Antioxidant agents
    Hassan, Sangar Ali
    Abdullah, Media Noori
    Aziz, Dara Muhammed
    EGYPTIAN JOURNAL OF CHEMISTRY, 2022, 65 (08): : 141 - 156
  • [44] A Library of Thiazolidin-4-one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt To Discover Novel Antidiabetic Agents
    Patel, Ashish D.
    Pasha, Thopallada Y.
    Lunagariya, Paras
    Shah, Umang
    Bhambharoliya, Tushar
    Tripathi, Rati K. P.
    CHEMMEDCHEM, 2020, 15 (13) : 1229 - 1242
  • [45] Molecular dynamic simulations based discovery and development of thiazolidin-4-one derivatives as EGFR inhibitors targeting resistance in non-small cell lung cancer (NSCLC)
    Karnik, Kshipra S.
    Sarkate, Aniket P.
    Lokwani, Deepak K.
    Tiwari, Shailee, V
    Azad, Rajaram
    Wakte, Pravin S.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (10): : 4696 - 4710
  • [46] Modeling and biological evaluation of 3.3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor
    Ottaná, R
    Mazzon, E
    Dugo, L
    Monforte, F
    Maccari, R
    Sautebin, L
    De Luca, G
    Vigorita, MG
    Alcaro, S
    Ortuso, F
    Caputi, AP
    Cuzzocrea, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 448 (01) : 71 - 80
  • [47] Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives
    Younis, Mohamed H.
    Mohammed, Eman R.
    Mohamed, Abdalla R.
    Abdel-Aziz, Marwa M.
    Georgey, Hanan H.
    Gawad, Nagwa M. Abdel
    BIOORGANIC CHEMISTRY, 2022, 124
  • [48] Synthesis of tetracyclic azasugars fused benzo[e][1,3]thiazin-4-one by the tandem Staudinger/aza-Wittig/cyclization and their HIV-RT inhibitory activity
    Shao, Jie
    Zhu, Mo
    Gao, Ligang
    Chen, Hua
    Li, Xiaoliu
    CARBOHYDRATE RESEARCH, 2018, 456 : 45 - 52
  • [49] 2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential
    Kumar, Davinder
    Aggarwal, Navidha
    Kumar, Harsh
    Kapoor, Garima
    Deep, Aakash
    Bibi, Shabana
    Sharma, Aastha
    Chopra, Hitesh
    Kumar Marwaha, Rakesh
    Alshammari, Abdulrahman
    Alharbi, Metab
    Hayee, Abdul
    PHARMACEUTICALS, 2023, 16 (06)
  • [50] Rational in silico drug design of HIV-RT inhibitors through G-QSAR and molecular docking study of 4-arylthio and 4-aryloxy-3-iodopyridine-2(1-H)-one derivative
    Panigrahi, Debadash
    Mishra, Amiyakanta
    Sahu, Susanta Kumar
    BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES, 2020, 9 (01)
12345