Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors

被引：18

作者：

Chen, Hua ^{[1
]}

Yang, Tianyu ^{[1
]}

Wei, Sinan ^{[1
]}

Zhang, Hongzhi ^{[1
]}

Li, Rui ^{[1
]}

Qin, Zhanbin ^{[1
]}

Li, Xiaoliu ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Bicyclic azasugar; Thiazolidin-4-one; HIV-RT inhibitor; Pummerer rearrangement; PUMMERER REACTION; INDOLIZIDINES;

D O I：

10.1016/j.bmcl.2012.09.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7041 / 7044

页数：4

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