Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors

被引：18

作者：

Chen, Hua ^{[1
]}

Yang, Tianyu ^{[1
]}

Wei, Sinan ^{[1
]}

Zhang, Hongzhi ^{[1
]}

Li, Rui ^{[1
]}

Qin, Zhanbin ^{[1
]}

Li, Xiaoliu ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Bicyclic azasugar; Thiazolidin-4-one; HIV-RT inhibitor; Pummerer rearrangement; PUMMERER REACTION; INDOLIZIDINES;

D O I：

10.1016/j.bmcl.2012.09.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7041 / 7044

页数：4

共 50 条

[1] Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives
Chen H.
Guo Z.
Yin Q.
Duan X.
Gu Y.
Li X.
Frontiers of Chemical Science and Engineering, 2011, 5 (2) : 231 - 237
[2] Synthesis of seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one and their HIV-RT inhibitory activity
Hou, Yuheng
Xing, Shunkai
Shao, Jie
Yin, Zhuqing
Hao, Le
Yang, Tianyu
Zhang, Hongzhi
Zhu, Mo
Chen, Hua
Li, Xiaoliu
CARBOHYDRATE RESEARCH, 2016, 429 : 105 - 112
[3] Synthesis and Characterization of New Thiazolidin-4-one Derivatives
Hu, Bao Xiang
Shen, Zhen Lu
Lu, Jun
Hu, Xin Quan
Mo, Wei Min
Sun, Nan
Xu, Dong
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (02) : 523 - 535
[4] Synthesis and Evaluation of Some New Thiazolidin-4-One Derivatives as Potential Antimicrobial Agents
Baviskar, B. A.
Khadabadi, S. S.
Deore, S. L.
JOURNAL OF CHEMISTRY, 2013, 2013
[5] DEVELOPMENT AND OPTIMIZATION OF THE SYNTHESIS OF NEW THIAZOLIDIN-4-ONE DERIVATIVES OF IBUPROFEN
Vasincu , Ioana
Apotrosoaei, Maria
Panzariu, Andreea
Buron, F.
Routier, S.
Profire, Lenuta
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2014, 118 (01): : 219 - 224
[6] Novel potential synthetic compounds from thiazolidin-4-one for infectious diseases
ASIAN BIOMEDICINE, 2017, 11 (05) : 393 - 393
[7] An efficient synthesis of new thiazolidin-4-one fused s-triazines as potential antimicrobial and anticancer agents
Patel, Amit B.
Chikhalia, Kishor H.
Kumari, Premlata
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2014, 18 (05) : 646 - 656
[8] SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME NEW THIAZOLIDIN-4-ONE DERIVATIVES
Apotrosoaei, Maria
Vasincu , Ioana
Constantin, Sandra
Buron, F.
Routier, S.
Profire, Lenuta
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2014, 118 (01): : 213 - 218
[9] Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii
D'Ascenzio, Melissa
Bizzarri, Bruna
De Monte, Celeste
Carradori, Simone
Bolasco, Adriana
Secci, Daniela
Rivanera, Daniela
Faulhaber, Nathan
Bordon, Claudia
Jones-Brando, Lorraine
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 86 : 17 - 30
[10] Thiazolidin-4-one and thiazinan-4-one derivatives analogous to rosiglitazone as potential antihyperglycemic and antidyslipidemic agents
Raza, Saman
Srivastava, Swayam P.
Srivastava, Daya S.
Srivastava, Arvind K.
Haq, W.
Katti, S. B.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 611 - 620

← 1 2 3 4 5 →