Antagonizing CXCR4 accelerates CD34+ cell mobilization

被引：1
|
作者：
Devine, SM [1 ]
机构：
[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
BLOOD | 2005年 / 106卷 / 12期
关键词：
D O I：
10.1182/blood-2005-09-3683
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A novel bicyclam CXCR4 antagonist, AMD3100, appears capable of mobilizing a fully functional hematopoietic allograft within just 6 hours following a single injection.
引用
收藏
页码：3685 / 3686
页数：2
相关论文
共 50 条
  • [41] Flow cytometric detection of the expression of CXCR4 on CD34+ cells and the distribution of lymphocyte subsets in allogeneic hematological grafts.
    Lu, LL
    Song, YP
    Ma, BG
    Zhu, XP
    Wei, XD
    Chen, ZZ
    BLOOD, 2005, 106 (11) : 382B - 383B
  • [42] Enhancement of chemotaxis migration of CD34+ hematopoietic stem cells and dendritic cells by a CXCR4 ligand-CTCE0021.
    Zhong, RK
    Ball, ED
    Wong, D
    Merzouk, A
    Arab, L
    Salari, H
    BLOOD, 2002, 100 (11) : 727A - 727A
  • [43] Adhesion of human haematopoietic (CD34+) stem cells to. human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4
    Crosby, Heather A.
    Lalor, Patricia F.
    Ross, Emma
    Newsome, Philip N.
    Adams, David H.
    JOURNAL OF HEPATOLOGY, 2009, 51 (04) : 734 - 749
  • [44] High leukapheresis component Cd34+ cell purity improves CD34+ cell purity following CD34+ cell selection.
    Webb, IJ
    Jiroutek, M
    Cohen, CA
    Schott, DM
    Doss, D
    Freeman, A
    Ritz, J
    Schlossman, RL
    Anderson, KC
    TRANSFUSION, 1998, 38 (10) : 46S - 46S
  • [45] Pathological mechanisms associated with CD34+ cell mobilization in idiopathic myelofibrosis.
    Xu, MJ
    Bruno, E
    Barosi, G
    Fruchtman, SM
    Prchal, JT
    Mahmud, N
    Rondelli, D
    Chao, J
    Hoffman, R
    BLOOD, 2003, 102 (11) : 147A - 147A
  • [46] Mobilization and transplantation of blood CD34+ cell in chronic lymphocytic leukemia (CLL)
    Itala, M
    Pelliniemi, TT
    Rajamaki, A
    Vanharanta, R
    Kauppila, M
    Remes, K
    BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 : 915 - 915
  • [47] A mathematical model of haemopoiesis as exemplified by CD34+ cell mobilization into the peripheral blood
    Obeyesekere, MN
    Berry, RW
    Spicer, PP
    Korbling, M
    CELL PROLIFERATION, 2004, 37 (04) : 279 - 294
  • [48] Quantitation of CXCR4 mRNA and correlation with CXCR4 cell surface expression on human CD4+T cells
    Anderson, M
    Gundeck-Fahey, J
    Ernst, J
    Younge, P
    Rivard, J
    Bartik, MM
    Asmus, C
    Krzyzek, R
    FASEB JOURNAL, 2002, 16 (04): : A153 - A153
  • [49] Coexpression of CXCR4 on CD34+cells changes during mobilization, affects the yield of mobilization and helps in identification of hematopietic progenitors at varied levels of differentiation
    Dlubek, D
    Drabczak-Skrzypek, D
    Dybko, J
    Lange, A
    BONE MARROW TRANSPLANTATION, 2003, 31 : S246 - S247
  • [50] Cytokine expansion culture of cord blood CD34+ cells induces marked and sustained changes in adhesion receptor and CXCR4 expressions
    Denning-Kendall, P
    Singha, S
    Bradley, B
    Hows, J
    STEM CELLS, 2003, 21 (01) : 61 - 70
12345