Antagonizing CXCR4 accelerates CD34+ cell mobilization

被引：1
|
作者：
Devine, SM [1 ]
机构：
[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
BLOOD | 2005年 / 106卷 / 12期
关键词：
D O I：
10.1182/blood-2005-09-3683
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A novel bicyclam CXCR4 antagonist, AMD3100, appears capable of mobilizing a fully functional hematopoietic allograft within just 6 hours following a single injection.
引用
收藏
页码：3685 / 3686
页数：2
相关论文
共 50 条
  • [31] Hypermethylation of CXCR4 promoter, and its reactivation by hypomethylating agent, in CD34+ cells from Primary Myelofibrosis patients
    Guglielmelii, Paola
    Bogani, Costanza
    Ponziani, Vanessa
    Poli, Giada
    Rosti, Vittorio
    Desterke, Cristophe
    Bosi, Alberto
    Le Bousse-Kerdiles, Marie Caroline
    Barosi, Giovanni
    Vannucchi, Alessandro M.
    BLOOD, 2007, 110 (11) : 462A - 462A
  • [32] CAMP-induced PKCζ activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors
    Goichberg, P
    Kalinkovich, A
    Borodovsky, N
    Tesio, M
    Petit, I
    Nagler, A
    Hardan, I
    Lapidot, T
    BLOOD, 2006, 107 (03) : 870 - 879
  • [33] Lenalidomide Upregulates CXCR4 on CD34+ Hematopoietic Cells Resulting In Increased Binding to Bone Marrow Niche and Inhibiting Mobilization Into Peripheral Blood In Multiple Myeloma Patients
    Li, Shirong
    Feng, Rentian
    Ma, Huihui
    Roodman, G. David
    Mapara, Markus Y.
    Lentzsch, Suzanne
    BLOOD, 2010, 116 (21) : 1661 - 1661
  • [34] MiR-9 Controls Chemotactic Activity of Cord Blood CD34+ Cells by Repressing CXCR4 Expression
    Ha, Tae Won
    Kang, Hyun Soo
    Kim, Tae-Hee
    Kwon, Ji Hyun
    Kim, Hyun Kvu
    Ryu, Aeli
    Jeon, Hyeji
    Han, Jaeseok
    Broxmeyer, Hal E.
    Hwang, Yongsung
    Lee, Yun Kyung
    Lee, Man Ryul
    INTERNATIONAL JOURNAL OF STEM CELLS, 2018, 11 (02) : 187 - 195
  • [35] Spontaneous and rapid reexpression of functional CXCR4 by human steady-state peripheral blood CD34+ cells
    Fumiya Hirayama
    Miki Yamaguchi
    Maki Yano
    Kazuta Yasui
    Yoshinori Horie
    Kayoko Matsumoto
    Nobuo Nagao
    Kenji Ikebuchi
    Hiroshi Azuma
    Hisami Ikeda
    Yoshihiko Tani
    International Journal of Hematology, 2003, 78 : 48 - 55
  • [36] Homogeneous expression of CXC chemokine receptor 4 (CXCR4) on G-CSF-mobilized peripheral blood CD34+ cells
    Rutella, S
    Pierelli, L
    Bonanno, G
    Scambia, G
    Leone, G
    Rumi, C
    BLOOD, 2000, 95 (12) : 4015 - 4016
  • [37] Targeting CXCR4, VLA4, and CXCR2 for Hematopoietic Stem Cell Mobilization
    Cancilla, Daniel
    Thakellapalli, Haresh
    Meyers, Marvin J.
    Rettig, Michael P.
    Chendamarai, Ezhilarasi
    Christ, Stephanie
    Karpova, Darja
    Ruminski, Peter G.
    Ritchey, Julie K.
    Morrow, Dwight M.
    Prinsen, Michael
    DiPersio, John F.
    BLOOD, 2019, 134
  • [38] Progenitor cell mobilization gets a boost from CXCR4 inhibition
    Leitman, SF
    BLOOD, 2005, 106 (05) : 1516 - 1517
  • [39] Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization
    Cancilla, Daniel
    Rettig, Michael P.
    Karpova, Darja
    Thakellapalli, Haresh
    Singh, Megh
    Meyers, Marvin J.
    Ruminski, Peter G.
    Christ, Stephanie
    Chendamarai, Ezhilarasi
    Gao, Feng
    Gehrs, Leah
    Ritchey, Julie K.
    Prinsen, Michael
    Dipersio, John F.
    BLOOD ADVANCES, 2024, 8 (06) : 1379 - 1383
  • [40] CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection
    Joseph Anderson
    Ramesh Akkina
    Retrovirology, 2
12345