New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities

被引：8
|
作者：
Gao, Xue-Mei [1 ,2 ]
Li, Yun-Qi [1 ,2 ]
Shu, Li-Dan [1 ,2 ]
Shen, Yan-Qiong [1 ,2 ]
Yang, Li-Ying [1 ,2 ]
Yang, Liu-Meng [4 ,5 ]
Zheng Yong-Tang [4 ,5 ]
Sun, Han-Dong [3 ]
Xiao, Wei-Lie [3 ]
Hu, Qiu-Fen [1 ,2 ]
机构：
[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
[4] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
[5] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2013年 / 34卷 / 03期
关键词：
Schisandra wilsoniana; Nortriterpenoid; Anti-HIV-1; activity; Cytotoxicity; HIGHLY OXYGENATED NORTRITERPENOIDS; ANTI-HIV ACTIVITY; ANTI-HIV-1; ACTIVITIES; DIBENZOCYCLOOCTADIENE LIGNANS; CHINENSIS;
D O I：
10.5012/bkcs.2013.34.3.827
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively.
引用
收藏
页码：827 / 830
页数：4
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