N,N-dimethyl-β-alanine as an inexpensive and efficient ligand for palladium-catalyzed Heck reaction

被引：125

作者：

Cui, Xin ^{[1
]}

Li, Zhe ^{[1
]}

Tao, Chuan-Zhou ^{[1
]}

Xu, Yu ^{[1
]}

Li, Juan ^{[1
]}

Liu, Lei ^{[1
]}

Guo, Qing-Xiang ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 12期

关键词：

D O I：

10.1021/ol060585n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N, N-Dimethyl-ss-alanine was found to be a more powerful phosphine-free ligand than the previously reported ligand, N, N-dimethylglycine, in the Pd-catalyzed Heck reaction for a variety of aryl bromides, aryl iodides, and activated aryl chlorides with a practical turnover number of 10(3). Both kinetic and theoretical studies suggested that N, N-dimethyl-ss-alanine led to faster oxidative addition of an aryl halide to Pd than N, N-dimethylglycine.

引用

页码：2467 / 2470

页数：4

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