Age-related macular degeneration and Alzheimer disease

被引：14
|
作者：
Cerman, Eren [1 ]
Eraslan, Muhsin [1 ]
Cekic, Osman [1 ]
机构：
[1] Marmara Univ, Dept Ophthalmol, Fac Med, Istanbul, Turkey
来源：
TURKISH JOURNAL OF MEDICAL SCIENCES | 2015年 / 45卷 / 05期
关键词：
Age-related macular degeneration; Alzheimer disease; amyloid-beta; drusen; senile plaques; SOLUBLE AMYLOID OLIGOMERS; COMPLEMENT ACTIVATION; OXIDATIVE STRESS; APOLIPOPROTEIN-E; POTENTIAL ROLE; BETA PEPTIDES; RISK-FACTORS; BLOOD-FLOW; DRUSEN; PATHOGENESIS;
D O I：
10.3906/sag-1406-146
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-beta accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
引用
收藏
页码：1004 / 1009
页数：6
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