Age-related macular degeneration and Alzheimer disease

被引：14

作者：

Cerman, Eren ^{[1
]}

Eraslan, Muhsin ^{[1
]}

Cekic, Osman ^{[1
]}

机构：

[1] Marmara Univ, Dept Ophthalmol, Fac Med, Istanbul, Turkey

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2015年 / 45卷 / 05期

关键词：

Age-related macular degeneration; Alzheimer disease; amyloid-beta; drusen; senile plaques; SOLUBLE AMYLOID OLIGOMERS; COMPLEMENT ACTIVATION; OXIDATIVE STRESS; APOLIPOPROTEIN-E; POTENTIAL ROLE; BETA PEPTIDES; RISK-FACTORS; BLOOD-FLOW; DRUSEN; PATHOGENESIS;

D O I：

10.3906/sag-1406-146

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-beta accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.

引用

页码：1004 / 1009

页数：6

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