A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

被引：8
|
作者：
Li, GL
Mehta, R
Srikrishnan, T
Nurco, DJ
Tabaczynski, WA
Alderfer, JL
Smith, KM
Dougherty, TJ
Pandey, RK [1 ]
机构：
[1] Roswell Pk Canc Inst, PDT Ctr, Div Chem, Buffalo, NY 14263 USA
[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源：
CHEMICAL COMMUNICATIONS | 2002年 / 11期
关键词：
D O I：
10.1039/b202280j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of meso-(2-formylvinyl) octaethylporphyrin with (CH3)(3)SiCN-Cu(OTf)(2) produced unexpected 10(3)-trimethyl-siloxyl and 10(3)-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 10(3)-position of the exocyclic benzene ring to form a novel benzochlorin.
引用
收藏
页码：1172 / 1173
页数：2
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