COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY - EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR

被引：30
|
作者：
SELMAN, SH
HAMPTON, JA
MORGAN, AR
KECK, RW
BALKANY, AD
SKALKOS, D
机构：
[1] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699
[2] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43699
[3] UNIV TOLEDO,DEPT MED CHEM,TOLEDO,OH 43699
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1993年 / 57卷 / 04期
关键词：
D O I：
10.1111/j.1751-1097.1993.tb02937.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An iminium salt of octaethylbenzochlorin with copper in the aromatic ring, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to be an effective photosensitizer in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin photosensitization was found to be minimal when drug-injected mice were illuminated in a solar simulator.
引用
收藏
页码：681 / 685
页数：5
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