Synthesis of Pyridines by Carbenoid-Mediated Ring Opening of 2H-Azirines

Roaming the range: The title reaction tolerates a wide range of substituents on the resulting pyridine ring using mild reaction conditions (see scheme; esp=α,α,α′,α′-tetramethyl-1,3- benzenedipropionic acid). The formation of the key intermediate is catalyst-controlled, and subsequent cyclization and oxidation affords pyridines in excellent yields. The method has been used for the efficient synthesis of polyarylpyridines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.