Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:: Identification of a novel mutation in inhA

被引：40
|
作者：
Leung, ETY [1 ]
Ho, PL [1 ]
Yuen, KY [1 ]
Woo, WL [1 ]
Lam, TH [1 ]
Kao, RY [1 ]
Seto, WH [1 ]
Yam, WC [1 ]
机构：
[1] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 03期
关键词：
D O I：
10.1128/AAC.50.3.1075-1078.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.
引用
收藏
页码：1075 / 1078
页数：4
相关论文
共 50 条
  • [41] Identification of a Mycobacterium tuberculosis strain with stable, low-level resistance to isoniazid
    Madison, BM
    Siddiqi, SH
    Heifets, L
    Gross, W
    Higgins, M
    Warren, N
    Thompson, A
    Morlock, G
    Ridderhof, JC
    JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (03) : 1294 - 1295
  • [42] The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis
    Slayden, RA
    Barry, CE
    MICROBES AND INFECTION, 2000, 2 (06) : 659 - 669
  • [43] HAEMIN AND ISONIAZID RESISTANCE OF MYCOBACTERIUM-TUBERCULOSIS
    KNOX, R
    JOURNAL OF GENERAL MICROBIOLOGY, 1955, 12 (02): : 191 - 202
  • [44] REVERSIBILITY OF ISONIAZID RESISTANCE DEVELOPED IN MYCOBACTERIUM TUBERCULOSIS
    INCZE, JS
    DISEASES OF THE CHEST, 1954, 26 (02): : 127 - 132
  • [45] Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis
    Flentie, Kelly
    Harrison, Gregory A.
    Tukenmez, Hasan
    Livny, Jonathan
    Good, James A. D.
    Sarkar, Souvik
    Zhu, Dennis X.
    Kinsella, Rachel L.
    Weiss, Leslie A.
    Solomon, Samantha D.
    Schene, Miranda E.
    Hansen, Mette R.
    Cairns, Andrew G.
    Kulen, Martina
    Wixe, Torbjorn
    Lindgren, Anders E. G.
    Chorell, Erik
    Bengtsson, Christoffer
    Krishnan, K. Syam
    Hultgren, Scott J.
    Larsson, Christer
    Almqvist, Fredrik
    Stallings, Christina L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (21) : 10510 - 10517
  • [46] RAPID IDENTIFICATION OF A POINT MUTATION OF THE MYCOBACTERIUM-TUBERCULOSIS CATALASE-PEROXIDASE (KATG) GENE ASSOCIATED WITH ISONIAZID RESISTANCE
    COCKERILL, FR
    UHL, JR
    TEMESGEN, Z
    ZHANG, Y
    STOCKMAN, L
    ROBERTS, GD
    WILLIAMS, DL
    KLINE, BC
    JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01): : 240 - 245
  • [47] Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates
    Ho, Yu Min
    Sun, Yong-Jiang
    Wong, Sin-Yew
    Lee, Ann S. G.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (09) : 4010 - 4012
  • [48] The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan
    Tseng, Shu-Ting
    Tai, Chun-Hsi
    Li, Chia-Ru
    Lin, Chin-Fu
    Shi, Zhi-Yuan
    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2015, 48 (03) : 249 - 255
  • [49] Molecular identification of mutations conferring resistance to rifampin, isoniazid and pyrazinamide among Mycobacterium tuberculosis isolates from Iran
    Haratiasl, Ahad Ali
    Hamzelou, Gholamreza
    Amini, Sirus
    Kardan-Yamchi, Jalil
    Haeili, Mehri
    Heidari, Fereshteh
    Feizabadi, Mohammad Mehdi
    JOURNAL OF CHEMOTHERAPY, 2020, 32 (02) : 75 - 82
  • [50] ON THE MUTATION TO STREPTOMYCIN RESISTANCE AND ISONIAZID RESISTANCE IN PAS-RESISTANT MYCOBACTERIUM-TUBERCULOSIS VAR HOMINIS
    TSUKAMURA, M
    MIURA, K
    NODA, Y
    JOURNAL OF ANTIBIOTICS, 1956, 9 (06): : 210 - 217
12345