Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:: Identification of a novel mutation in inhA

被引：40
|
作者：
Leung, ETY [1 ]
Ho, PL [1 ]
Yuen, KY [1 ]
Woo, WL [1 ]
Lam, TH [1 ]
Kao, RY [1 ]
Seto, WH [1 ]
Yam, WC [1 ]
机构：
[1] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 03期
关键词：
D O I：
10.1128/AAC.50.3.1075-1078.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.
引用
收藏
页码：1075 / 1078
页数：4
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