Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

被引：54
|
作者：
Inabe, K [1 ]
Kurosaki, T [1 ]
机构：
[1] Kansai Med Univ, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506, Japan
来源：
BLOOD | 2002年 / 99卷 / 02期
关键词：
D O I：
10.1182/blood.V99.2.584
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
CD19 is a coreceptor that amplifies signaling Initiated by antigen cross-linking of the B-cell antigen receptor (BCR). CD19 can also signal independently of BCR coligation. This study shows that (B) under bar-(c) under bar ell adaptor for phosphoinositide 3-kinase (BCAP), previously characterized as a substrate of the tyrosine kinases upon BCR engagement, Is phosphorylated by cross-linking of CD19. Tyrosine phosphorylation of BCAP, mediated by Lyn, provides binding site(s) for phosphoinositide 3-kinase (PI3K), thereby participating in Akt activation. Thus, these results provide evidence that BCAP serves as an adaptor molecule for CD19 to activate the PI3K pathway In B cells. (Blood. 2002;99: 584-589) (C) 2002 by The American Society of Hematology.
引用
收藏
页码：584 / 589
页数：6
相关论文
共 50 条
  • [41] Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling
    Craddock, BL
    Orchiston, EA
    Hinton, HJ
    Welham, MJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (15) : 10633 - 10640
  • [42] Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling
    Miyazaki, Mitsunori
    McCarthy, John J.
    Fedele, Mark J.
    Esser, Karyn A.
    JOURNAL OF PHYSIOLOGY-LONDON, 2011, 589 (07): : 1831 - 1846
  • [43] CD38 ligation in immature B cells causes tyrosine phosphorylation of CD19 and promotes its association with lyn and phosphatydilinositol 3-kinase.
    Kitanaka, A
    Ito, C
    Campana, D
    BLOOD, 1996, 88 (10) : 1848 - 1848
  • [44] Selective inhibitors of phosphoinositide 3-kinase delta: moculators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies
    Puri, Kamal D.
    Gold, Michael R.
    FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [45] Role of phosphatidylinositol 3-kinase/AKT pathway in diffuse large B-cell lymphoma survival
    Uddin, S
    Hussain, AR
    Bavi, P
    Siraj, AK
    Al-Kuraya, KS
    BLOOD, 2005, 106 (11) : 282B - 282B
  • [46] Phosphoinositide 3-kinase activity leads to NF-κB activation through interacting with tyrosine-phosphorylated IκB-α and contributing to tyrosine phosphorylation of p65 NF-κB
    Kang, JHL
    Lee, HS
    Pack, IS
    Castranova, V
    FASEB JOURNAL, 2002, 16 (05): : A1161 - A1161
  • [47] Activation and tyrosine phosphorylation of protein kinase C δ in response to B cell antigen receptor stimulation
    Popoff, IJ
    Deans, JP
    MOLECULAR IMMUNOLOGY, 1999, 36 (15-16) : 1005 - 1016
  • [48] Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cγ pathways
    Marshall, AJ
    Niiro, H
    Yun, TJ
    Clark, EA
    IMMUNOLOGICAL REVIEWS, 2000, 176 : 30 - 46
  • [49] CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
    Fujimoto, M
    Poe, JC
    Jansen, PJ
    Sato, S
    Tedder, TF
    JOURNAL OF IMMUNOLOGY, 1999, 162 (12): : 7088 - 7094
  • [50] The c-abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19
    Zipfel, PA
    Grove, M
    Blackburn, K
    Fujimoto, M
    Tedder, TF
    Pendergast, AM
    JOURNAL OF IMMUNOLOGY, 2000, 165 (12): : 6872 - 6879
12345