Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

被引：54

作者：

Inabe, K ^{[1
]}

Kurosaki, T ^{[1
]}

机构：

[1] Kansai Med Univ, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506, Japan

来源：

BLOOD | 2002年 / 99卷 / 02期

关键词：

D O I：

10.1182/blood.V99.2.584

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD19 is a coreceptor that amplifies signaling Initiated by antigen cross-linking of the B-cell antigen receptor (BCR). CD19 can also signal independently of BCR coligation. This study shows that (B) under bar-(c) under bar ell adaptor for phosphoinositide 3-kinase (BCAP), previously characterized as a substrate of the tyrosine kinases upon BCR engagement, Is phosphorylated by cross-linking of CD19. Tyrosine phosphorylation of BCAP, mediated by Lyn, provides binding site(s) for phosphoinositide 3-kinase (PI3K), thereby participating in Akt activation. Thus, these results provide evidence that BCAP serves as an adaptor molecule for CD19 to activate the PI3K pathway In B cells. (Blood. 2002;99: 584-589) (C) 2002 by The American Society of Hematology.

引用

页码：584 / 589

页数：6

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