Differentiating agents do not induce a true hairy cell phenotype in B-CLL cells in vitro

被引：1
|
作者：
Gartenhaus, R [1 ]
Hoffman, M [1 ]
Fuchs, A [1 ]
Billet, H [1 ]
Wang, P [1 ]
Gentile, P [1 ]
Rai, K [1 ]
机构：
[1] LONG ISL JEWISH MED CTR,DEPT MED,DIV HEMATOL ONCOL,NEW HYDE PK,NY 11042
来源：
LEUKEMIA & LYMPHOMA | 1996年 / 22卷 / 1-2期
关键词：
chronic lymphocytic leukemia (CLL); hairy cell leukemia (HCL); differentiating agents; phorbol esters; lactones; retinoids;
D O I：
10.3109/10428199609051734
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B-Chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) are both differentiated B-cell lymphoproliferative disorders. Prior studies have suggested that phorbol esters and the macrocyclic lactone Bryostatin-1, which are both protein kinase-C activators, can induce the differentiation of B-CLL cells into HCL cells in vitro, as evidenced by morphology, phenotype and TRAP activity. The differentiating effect of all-trans retinoic acid on B-CLL cells has been less extensively studied. We studied the effects of incubating adherence purified B-CLL cells with phorbol myristic acetate (PMA), all-trans retinoic acid (ATRA), and Bryostatin-1. None of these agents induced a true HCL phenotype (CD5-, CD11c/CD25 coexpression) under the conditions studied.
引用
收藏
页码：97 / &
页数：6
相关论文
共 50 条
  • [41] B-CLL CELLS EXPRESS TRUE ENDOGENOUS E-RECEPTOR AFTER CULTURE WITH T-CELLS AND MITOGENS
    WORMAN, CP
    CAWLEY, JC
    BRITISH JOURNAL OF HAEMATOLOGY, 1982, 52 (02) : 205 - 210
  • [42] Induction of a CTL-like phenotype in B-CLL cells stimulated with interleukin 21 and CpG oligodeoxynucleotides
    Jahrsdoerfer, B.
    Ebel, V.
    Beyer, T.
    Sontheimer, K.
    Dahlke, K.
    Blackwell, S. E.
    Weiner, G. J.
    Simmet, T.
    Hagn, M.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2010, 381 : 92 - 92
  • [43] Distinct phenotype of chronic lymphocytic leukaemia (B-CLL) cells engrafting in NOD/SCID mice.
    Ebeling, Peter
    Durig, Jan
    Grabellus, Florian
    Seeber, Siegfried
    Duehrsen, Ulrich
    Moritz, Thomas
    BLOOD, 2006, 108 (11) : 798A - 799A
  • [44] Fludarabine and chlorambucil induce identical in vitro apoptotic responses and this may explain the frequent development of cross-resistance in B-CLL cells.
    Bentley, P
    Hoy, T
    Pepper, C
    BLOOD, 1998, 92 (10) : 192B - 192B
  • [45] Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides
    Jahrsdoerfer, Bernd
    Blackwell, Sue E.
    Hagn, Magdalena
    Ebel, Verena
    Beyer, Thamara
    Sontheimer, Kai
    Dahlke, Karen
    Weiner, George
    Simmet, Thomas
    BLOOD, 2010, 116 (21) : 1594 - 1594
  • [46] Induction of an immunogenic and apoptotic phenotype in B chronic lymphocytic leukemia (B-CLL) cells by immunostimulatory PyNTTTTGT oligodeoxynucleotides (ODN).
    Dupont, J
    Flo, J
    Zorzopulos, J
    Riveros, D
    Lopez, R
    Garay, G
    Cacchione, R
    BLOOD, 2003, 102 (11) : 429A - 430A
  • [47] CD317 Is Over-Expressed in B-CLL and Promotes Cell Growth In Vitro
    Gong, S.
    Osei, E. S.
    Kaplan, D.
    Chen, Y.
    Meyerson, H.
    MODERN PATHOLOGY, 2013, 26 : 329A - 329A
  • [48] CD317 Is Over-Expressed in B-CLL and Promotes Cell Growth In Vitro
    Gong, S.
    Osei, E. S.
    Kaplan, D.
    Chen, Y.
    Meyerson, H.
    LABORATORY INVESTIGATION, 2013, 93 : 329A - 329A
  • [49] Identification of Two Novel Chemokines (CCL2 and CXCL2) in B-Chronic Lymphocytic Leukaemia (B-CLL) and Prolonged Survival of Primary B-CLL Cells in Vitro
    Gill, Devinder
    Burgess, Melinda
    Knop, Louise
    Mollee, Peter
    McMillan, Nigel
    BLOOD, 2008, 112 (11) : 1082 - 1083
  • [50] CPG oligodeoxynucleotides enhance immunogenicity in vitro in all cytogenetic subgroups of B-cell chronic lymphocytic leukemia (B-CLL), but preferentially augment apoptosis in B-CLL with good prognosis cytogenetics
    Jahrsdoerfer, B
    Blackwell, S
    Wooldridge, J
    Taylor, C
    Weiner, G
    JOURNAL OF IMMUNOTHERAPY, 2004, 27 (06) : S35 - S36
12345