Differentiating agents do not induce a true hairy cell phenotype in B-CLL cells in vitro

被引：1
|
作者：
Gartenhaus, R [1 ]
Hoffman, M [1 ]
Fuchs, A [1 ]
Billet, H [1 ]
Wang, P [1 ]
Gentile, P [1 ]
Rai, K [1 ]
机构：
[1] LONG ISL JEWISH MED CTR,DEPT MED,DIV HEMATOL ONCOL,NEW HYDE PK,NY 11042
来源：
LEUKEMIA & LYMPHOMA | 1996年 / 22卷 / 1-2期
关键词：
chronic lymphocytic leukemia (CLL); hairy cell leukemia (HCL); differentiating agents; phorbol esters; lactones; retinoids;
D O I：
10.3109/10428199609051734
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B-Chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) are both differentiated B-cell lymphoproliferative disorders. Prior studies have suggested that phorbol esters and the macrocyclic lactone Bryostatin-1, which are both protein kinase-C activators, can induce the differentiation of B-CLL cells into HCL cells in vitro, as evidenced by morphology, phenotype and TRAP activity. The differentiating effect of all-trans retinoic acid on B-CLL cells has been less extensively studied. We studied the effects of incubating adherence purified B-CLL cells with phorbol myristic acetate (PMA), all-trans retinoic acid (ATRA), and Bryostatin-1. None of these agents induced a true HCL phenotype (CD5-, CD11c/CD25 coexpression) under the conditions studied.
引用
收藏
页码：97 / &
页数：6
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