Effect of PVP with a Mesh-Hold bone-filling mesh bag and different viscosities of bone cement in the treatment of osteoporotic vertebral compression fractures

Objective: To investigate the effect of percutaneous vertebroplasty (PVP) with Mesh-Hold (TM) bone-filling mesh bag and different viscosities of bone cement in the treatment of osteoporotic vertebral compression fractures (OVCF). Methods: A total of 105 patients with OVCF were randomly divided into group A (n=35, Mesh-Hold (TM) bone-filling mesh bag PVP), group B (n=35, high viscosity bone cement PVP, 7 mL), and group C (n=35, low-viscosity bone cement PVP, 3 mL). VAS was used to assess thoracolumbar pain and ODI was used to assess thoracolumbar function. The VAS and ODI scores before surgery and at 1 day, 1 month, 6 months, and 12 months after surgery, bone cement leakage, uneven cement distribution, and injection volume within 1 month after operation were compared between the two groups. Results: The VAS and ODI scores of groups A, B and C were significantly reduced at 1 day, 1 month, 6 months, and 12 months after surgery as compared with those before surgery (P<0.05). The leakage rates of bone cement in groups A and B were 8.57% and 11.43%, which were significantly lower than that in group C (28.57%) (P<0.05). The uneven distribution rates of bone cement in groups A and B were 2.86%, which were significantly lower than that in group C (17.14%) (P<0.05); there was no significant difference in the injection volume of bone cement among the three groups (P>0.05). Conclusion: PVP with Mesh-Hold (TM) bone-filling mesh bag and high-viscosity bone cement can quickly relieve pain, and reduce bone cement leakage and uneven distribution.