TSC on the peroxisome controls mTORC1

被引：13
|
作者：
Benjamin, Don [1 ]
Hall, Michael N. [1 ]
机构：
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 10期
关键词：
ACTIVATION; STRESS;
D O I：
10.1038/ncb2849
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.
引用
收藏
页码：1135 / 1136
页数：2
相关论文
共 50 条
  • [31] TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
    Plescher, Monika
    Teleman, Aurelio A.
    Demetriades, Constantinos
    SCIENTIFIC REPORTS, 2015, 5
  • [32] Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding
    Amemiya, Yuna
    Ioi, Yuichiro
    Araki, Makoto
    Kontani, Kenji
    Maki, Masatoshi
    Shibata, Hideki
    Takahara, Terunao
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2025, 301 (02)
  • [33] Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
    Menon, Suchithra
    Dibble, Christian C.
    Talbott, George
    Hoxhaj, Gerta
    Valvezan, Alexander J.
    Takahashi, Hidenori
    Cantley, Lewis C.
    Manning, Brendan D.
    CELL, 2014, 156 (04) : 771 - 785
  • [34] ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    Alexander, Angela
    Cai, Sheng-Li
    Kim, Jinhee
    Nanez, Adrian
    Sahin, Mustafa
    MacLean, Kirsteen H.
    Inoki, Ken
    Guan, Kun-Liang
    Shen, Jianjun
    Person, Maria D.
    Kusewitt, Donna
    Mills, Gordon B.
    Kastan, Michael B.
    Walker, Cheryl Lyn
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) : 4153 - 4158
  • [35] TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
    Monika Plescher
    Aurelio A. Teleman
    Constantinos Demetriades
    Scientific Reports, 5
  • [36] mTORC1 controls glucose metabolism in bovine mammary epithelial cells
    Guesthier, M.
    Huang, J.
    Zhao, X.
    Burgos, S.
    JOURNAL OF ANIMAL SCIENCE, 2018, 96 : 261 - 262
  • [37] Protein kinase C controls lysosome biogenesis independently of mTORC1
    Yang Li
    Meng Xu
    Xiao Ding
    Chen Yan
    Zhiqin Song
    Lianwan Chen
    Xiahe Huang
    Xin Wang
    Youli Jian
    Guihua Tang
    Changyong Tang
    Yingtong Di
    Shuzhen Mu
    Xuezhao Liu
    Kai Liu
    Ting Li
    Yingchun Wang
    Long Miao
    Weixiang Guo
    Xiaojiang Hao
    Chonglin Yang
    Nature Cell Biology, 2016, 18 : 1065 - 1077
  • [38] Protein kinase C controls lysosome biogenesis independently of mTORC1
    Li, Yang
    Xu, Meng
    Ding, Xiao
    Yan, Chen
    Song, Zhiqin
    Chen, Lianwan
    Huang, Xiahe
    Wang, Xin
    Jian, Youli
    Tang, Guihua
    Tang, Changyong
    Di, Yingtong
    Mu, Shuzhen
    Liu, Xuezhao
    Liu, Kai
    Li, Ting
    Wang, Yingchun
    Miao, Long
    Guo, Weixiang
    Hao, Xiaojiang
    Yang, Chonglin
    NATURE CELL BIOLOGY, 2016, 18 (10) : 1065 - 1077
  • [39] Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma
    Dong, Pingping
    Wang, Xiaoxiao
    Liu, Longzi
    Tang, Wenqing
    Ma, Lijie
    Zeng, Wenjiao
    Sun, Shaoyang
    Zhang, Li
    Zhang, Ningping
    Shen, Xizhong
    Janssen, Harry L. A.
    Dong, Ling
    Zhang, Si
    Chen, She
    JOURNAL OF HEPATOLOGY, 2020, 73 (06) : 1446 - 1459
  • [40] G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    Prentzell, Mirja Tamara
    Rehbein, Ulrike
    Sandoval, Marti Cadena
    De Meulemeester, Ann-Sofie
    Baumeister, Ralf
    Brohee, Laura
    Berdel, Bianca
    Bockwoldt, Mathias
    Carroll, Bernadette
    Chowdhury, Suvagata Roy
    von Deimling, Andreas
    Demetriades, Constantinos
    Figlia, Gianluca
    de Araujo, Mariana Eca Guimaraes
    Heberle, Alexander M.
    Heiland, Ines
    Holzwarth, Birgit
    Huber, Lukas A.
    Jaworski, Jacek
    Kedra, Magdalena
    Kern, Katharina
    Kopach, Andrii
    Korolchuk, Viktor, I
    van't Land-Kuper, Ineke
    Macias, Matylda
    Nellist, Mark
    Palm, Wilhelm
    Pusch, Stefan
    Pittol, Jose Miguel Ramos
    Reil, Michele
    Reintjes, Anja
    Reuter, Friederike
    Sampson, Julian R.
    Scheldeman, Chloe
    Siekierska, Aleksandra
    Stefan, Eduard
    Teleman, Aurelio A.
    Thomas, Laura E.
    Torres-Quesada, Omar
    Trump, Saskia
    West, Hannah D.
    de Witte, Peter
    Woltering, Sandra
    Yordanov, Teodor E.
    Zmorzynska, Justyna
    Opitz, Christiane A.
    Thedieck, Kathrin
    CELL, 2021, 184 (03) : 655 - +
12345