TSC on the peroxisome controls mTORC1

被引：13
|
作者：
Benjamin, Don [1 ]
Hall, Michael N. [1 ]
机构：
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 10期
关键词：
ACTIVATION; STRESS;
D O I：
10.1038/ncb2849
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.
引用
收藏
页码：1135 / 1136
页数：2
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