Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines

被引：0

作者：

Borne, Ronald F. ^{[2
,3
]}

Levi, Mark S. ^{[1
]}

Khan, M. O. Faruk ^{[4
]}

Wilson, Norman H. ^{[5
]}

机构：

[1] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Lab Appl Drug Design & Synth, University, MS 38677 USA

[4] SW Oklahoma State Univ, Coll Pharm, Weatherford, OK 73096 USA

[5] Univ Edinburgh, Sch Biomed Sci, Edinburgh, Midlothian, Scotland

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 01期

关键词：

Addiction; Ibogaine; Isoquinuclidine; Parallel synthesis; Anti-addictive; IBOGAINE ANALOGS;

D O I：

10.2174/157018009787158517

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. The presence of the isoquinuclidine ring system in the structure of ibogaine became the lead for the design of a 16-member library of N-aryl isoquinuclidines, where pyridine, pyrimidine and quinoline ring systems were attached directly to the bicyclic nitrogen. A solution-phase method for their synthesis is described.

引用

页码：78 / 81

页数：4

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