Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines

被引：0

作者：

Borne, Ronald F. ^{[2
,3
]}

Levi, Mark S. ^{[1
]}

Khan, M. O. Faruk ^{[4
]}

Wilson, Norman H. ^{[5
]}

机构：

[1] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Lab Appl Drug Design & Synth, University, MS 38677 USA

[4] SW Oklahoma State Univ, Coll Pharm, Weatherford, OK 73096 USA

[5] Univ Edinburgh, Sch Biomed Sci, Edinburgh, Midlothian, Scotland

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 01期

关键词：

Addiction; Ibogaine; Isoquinuclidine; Parallel synthesis; Anti-addictive; IBOGAINE ANALOGS;

D O I：

10.2174/157018009787158517

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. The presence of the isoquinuclidine ring system in the structure of ibogaine became the lead for the design of a 16-member library of N-aryl isoquinuclidines, where pyridine, pyrimidine and quinoline ring systems were attached directly to the bicyclic nitrogen. A solution-phase method for their synthesis is described.

引用

页码：78 / 81

页数：4

共 50 条

[21] Solution-Phase Parallel Synthesis of Hsp90 Inhibitors
Cho-Schultz, Sujin
Patten, Monica Jo
Huang, Buwen
Elleraas, Jeff
Gajiwala, Ketan S.
Hickey, Michael J.
Wang, Jeff
Mehta, Pramod P.
Kang, Ping
Gehring, Michael R.
Kung, Pei-Pei
Sutton, Scott C.
JOURNAL OF COMBINATORIAL CHEMISTRY, 2009, 11 (05): : 860 - 874
[22] Solution-phase parallel synthesis of S-DABO analogues
Togninelli, A
Carmi, C
Petricci, E
Mugnaini, C
Massa, S
Corelli, F
Botta, M
TETRAHEDRON LETTERS, 2006, 47 (01) : 65 - 67
[23] Parallel Solution-Phase Synthesis of an Adenosine Antibiotic Analog Library
Moukha-chafiq, Omar
Reynolds, Robert C.
ACS COMBINATORIAL SCIENCE, 2013, 15 (03) : 147 - 152
[24] A straightforward protocol for the solution-phase parallel synthesis of ceramide analogues
Grijalvo, Santiago
Matabosch, Xavier
Llebaria, Amadeu
Delgado, Antonio
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (01) : 150 - 155
[25] Parallel solution-phase synthesis of tetra-substituted purines
Bai, X
Dang, Q
Yang, JX
Liu, JL
Wei, ZL
Zhang, HB
Wu, JC
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U161 - U161
[26] Efficient solution-phase parallel synthesis of 4-substituted N-protected piperidines
Wang, XY
Kauppi, AM
Olsson, R
Almqvist, F
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (23) : 4586 - 4592
[27] Solution-phase parallel synthesis of carbamates using polymer-bound N-hydroxysuccinimide
Sumiyoshi, H
Shimizu, T
Katoh, M
Baba, Y
Sodeoka, M
ORGANIC LETTERS, 2002, 4 (22) : 3923 - 3926
[28] A solution-phase parallel synthesis of alkylated guanidines from thioisocyanates and amines
Andrey V. Bogolubsky
Alexander Grishchenko
Sergey E. Pipko
Anzhelika Konovets
Alexander Chuprina
Andrey Tolmachev
Alexander N. Boyko
Alexey Chekotylo
Oleg Lukin
Molecular Diversity, 2013, 17 : 471 - 477
[29] New fluorous tag strategy for solution-phase parallel synthesis.
Zhang, W
Chen, CHT
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U416 - U416
[30] AutoChem: Automated solution-phase parallel synthesis and purification via HPLC
Tommasi, RA
Whaley, LW
Marepalli, HR
JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (05): : 447 - 449

← 1 2 3 4 5 →