Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

被引：41
|
作者：
Shi, Tie-Jun Sten [1 ]
Liu, Su-Xing Leslie [1 ]
Hammarberg, Henrik [2 ]
Watanabe, Masahiko [3 ]
Xu, Zhi-Qing David [1 ]
Hokfelt, Tomas [1 ]
机构：
[1] Karolinska Inst, Sect Hand Surg, Dept Neurosci, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Sect Hand Surg, Dept Clin Sci & Educ, S-17177 Stockholm, Sweden
[3] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 50期
基金：
英国医学研究理事会;
关键词：
galanin receptor 2; nerve injury; neuropeptide; pain treatment; sensory neuron;
D O I：
10.1073/pnas.0810899105
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase beta 3 (PLC beta 3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.
引用
收藏
页码：20004 / 20008
页数：5
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