Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

被引：41
|
作者：
Shi, Tie-Jun Sten [1 ]
Liu, Su-Xing Leslie [1 ]
Hammarberg, Henrik [2 ]
Watanabe, Masahiko [3 ]
Xu, Zhi-Qing David [1 ]
Hokfelt, Tomas [1 ]
机构：
[1] Karolinska Inst, Sect Hand Surg, Dept Neurosci, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Sect Hand Surg, Dept Clin Sci & Educ, S-17177 Stockholm, Sweden
[3] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 50期
基金：
英国医学研究理事会;
关键词：
galanin receptor 2; nerve injury; neuropeptide; pain treatment; sensory neuron;
D O I：
10.1073/pnas.0810899105
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase beta 3 (PLC beta 3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.
引用
收藏
页码：20004 / 20008
页数：5
相关论文
共 50 条
  • [31] The Role of Nerve Growth Factor in Neuropathic Pain Inhibition Produced by Resiniferatoxin Treatment in the Dorsal Root Ganglia
    Tender, Gabriel C.
    Li, Yuan-Yuan
    Cui, Jian-Guo
    NEUROSURGERY, 2013, 73 (01) : 158 - 165
  • [32] RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain
    Ray, Pradipta R.
    Shiers, Stephanie
    Caruso, James P.
    Tavares-Ferreira, Diana
    Sankaranarayanan, Ishwarya
    Uhelski, Megan L.
    Li, Yan
    North, Robert Y.
    Tatsui, Claudio
    Dussor, Gregory
    Burton, Michael D.
    Dougherty, Patrick M.
    Price, Theodore J.
    BRAIN, 2023, 146 (02) : 749 - 766
  • [33] Nerve Growth Factor in the Dorsal Root Ganglia Modulates Neuropathic Pain Inhibition After Resiniferatoxin Treatment
    Tender, Gabriel Claudiu
    Cui, Jian Guo
    NEUROSURGERY, 2010, 67 (02) : 550 - 550
  • [34] Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion
    Wu, Yao
    Wang, Fangyong
    MOLECULAR PAIN, 2023, 19
  • [35] Activation of MSK-1 exacerbates neuropathic pain through histone H3 phosphorylation in the rats' dorsal root ganglia and spinal dorsal horn
    Wang, Li
    Gao, Yan
    Qiao, Yiming
    Wang, Xueli
    Liang, Zongyi
    Xu, Ji-Tian
    Li, Liren
    BRAIN RESEARCH BULLETIN, 2024, 219
  • [36] Neurotrophin-3 and Tyrosine Kinase C Have Modulatory Effects on Neuropathic Pain in the Rat Dorsal Root Ganglia COMMENT
    Richardson, Peter
    NEUROSURGERY, 2011, 68 (04) : 1055 - 1055
  • [37] Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation
    Liu, Feng-Yu
    Sun, Yan-Ni
    Wang, Fa-Tian
    Li, Qian
    Su, Li
    Zhao, Zi-Fang
    Meng, Xiang-Ling
    Zhao, Hong
    Wu, Xi
    Sun, Qian
    Xing, Guo-Gang
    Wan, You
    BRAIN RESEARCH, 2012, 1427 : 65 - 77
  • [38] Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats
    Bai, Liying
    Wang, Xinru
    Li, Zhisong
    Kong, Cunlong
    Zhao, Yonghui
    Qian, Jun-Liang
    Kan, Quancheng
    Zhang, Wei
    Xu, Ji-Tian
    NEUROSCIENCE BULLETIN, 2016, 32 (01) : 27 - 40
  • [39] Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats
    Liying Bai
    Xinru Wang
    Zhisong Li
    Cunlong Kong
    Yonghui Zhao
    Jun-Liang Qian
    Quancheng Kan
    Wei Zhang
    Ji-Tian Xu
    Neuroscience Bulletin, 2016, 32 : 27 - 40
  • [40] Voltage dependent calcium channel apha-2-delta subunit mRNA in the spinal cord and dorsal root ganglia in a rat model of neuropathic pain.
    Philp, L
    Williams, RG
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 71 - 71
12345