Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

被引：41

作者：

Shi, Tie-Jun Sten ^{[1
]}

Liu, Su-Xing Leslie ^{[1
]}

Hammarberg, Henrik ^{[2
]}

Watanabe, Masahiko ^{[3
]}

Xu, Zhi-Qing David ^{[1
]}

Hokfelt, Tomas ^{[1
]}

机构：

[1] Karolinska Inst, Sect Hand Surg, Dept Neurosci, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Sect Hand Surg, Dept Clin Sci & Educ, S-17177 Stockholm, Sweden

[3] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 50期

基金：

英国医学研究理事会;

关键词：

galanin receptor 2; nerve injury; neuropeptide; pain treatment; sensory neuron;

D O I：

10.1073/pnas.0810899105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase beta 3 (PLC beta 3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.

引用

页码：20004 / 20008

页数：5

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