Evaluation of the Antimicrobial Activity of Some 4H-Pyrano[3,2-h]quinoline,7H-Pyrimido[4′,5′:6,5]pyrano[3,2-h]quinoline Derivatives

被引：2

作者：

Mohamed, Hany M. ^{[2
,3
]}

Radini, Ibrahim A. ^{[3
]}

Al-Ghamdi, Abdullah M. ^{[1
]}

El-Agrody, Ahmed M. ^{[1
,2
]}

机构：

[1] King Khalid Univ, Fac Sci, Dept Chem, Abha 61413, Saudi Arabia

[2] Al Azhar Univ, Fac Sci, Dept Chem, Cairo 11884, Egypt

[3] Jazan Univ, Dept Chem, Fac Sci, Jazan 2097, Saudi Arabia

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 08期

关键词：

8-Hydroxyquinoline; 8-Hydroxy-2-methylquinoline; (E) 2-(4-Chloro/bromo/-fluorostyryl)-8-hydroxyquinoline; Antimicrobial; SAR; ALPHA-CYANOCINNAMONITRILES; HETEROCYCLIC SYNTHESIS; INTEGRASE INHIBITORS; BIOLOGICAL-ACTIVITY; ANTITUMOR; CONDENSATION; COUMARIN; AGENTS;

D O I：

10.2174/15701808113109990002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 4H-pyrano[3,2-h]quinolone (3, 5, 7, 8, 10, 11, 14, 15, 16 and 17) and 7H-pyrimido[4',5':-6,5] pyrano[3,2-h]quinoline derivatives (9, 12, 13, 18) were prepared. These compounds were tested in vitro for their antimicrobial activity to show congruent results against the most tested microorganisms as compared with the standards Ampicillin, Streptomycin, Mycostatine and Clotrimazole. The structure activity relationship (SAR) studies of 3 and its analog compounds revealed higher potent antimicrobial activity against the most tested microorganisms. These data indicated that the activity of compounds was considerably attributed to the presence of the electrondonating groups in combination with the electron-withdrawing groups in 4H-pyrano[3,2-h] quinoline moiety. Incorporating a pyrimidine nucleus with pyranoquinoline moiety resulted in changing the potency for some compound. The structures of these compounds were established on the basis of spectral data.

引用

页码：758 / 775

页数：18

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