Furo[3,2-h]quinoline derivatives as a gastric H+/K+-ATPase inhibitors

被引：0
|
作者：
Kang, SK
Cho, SY
Kim, SS
Cheon, HG
Choi, JK
Yum, EK
机构：
[1] Korea Res Inst Chem Technol, Taejon 305600, South Korea
[2] Chungnam Natl Univ, Dept Chem, Taejon 305764, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2002年 / 23卷 / 03期
关键词：
furo[3,2-h]quinoline; gastric H+/+KT-ATPase inhibitors; anti-secretory;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Furo[3,2-h]quinoline derivatives were synthesized as a gastric H-/K--ATPase inhibitors. The oxycyclization of 7 and 8-positions in quinoline potentiated the inhibitory activity, while no significant changes in biological activity were observed by the variation of substituents in furan ring. The several faro[3,2-h]quinoline derivatives were worthy of in vivo investigation for their anti-secretory and anti-ulcer activity.
引用
收藏
页码：454 / 458
页数：5
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