Malignant melanoma arising in a primary mediastinal germ cell tumor

被引：4
|
作者：
Lee, Sherry [1 ]
Chornenkyy, Yevgen [1 ]
Swete, Michael T. [1 ]
Kim, Samuel S. [2 ]
Bharat, Ankit [2 ]
Yang, Ximing J. [1 ]
Yeldandi, Anjana [1 ]
机构：
[1] Northwestern Univ, Dept Pathol, Feinberg Sch Med, 303 E Chicago Ave, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Div Thorac Surg, 676 N St Clair St, Chicago, IL 60611 USA
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 11期
关键词：
Melanoma; Mediastinal germ cell tumor; Teratoma; Molecular analysis; KIT; NRAS; KIT; COMPONENTS; TERATOMA;
D O I：
10.1016/j.prp.2020.153210
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histo-pathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.
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页数：6
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