Malignant melanoma arising in a primary mediastinal germ cell tumor

被引：4

作者：

Lee, Sherry ^{[1
]}

Chornenkyy, Yevgen ^{[1
]}

Swete, Michael T. ^{[1
]}

Kim, Samuel S. ^{[2
]}

Bharat, Ankit ^{[2
]}

Yang, Ximing J. ^{[1
]}

Yeldandi, Anjana ^{[1
]}

机构：

[1] Northwestern Univ, Dept Pathol, Feinberg Sch Med, 303 E Chicago Ave, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Div Thorac Surg, 676 N St Clair St, Chicago, IL 60611 USA

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 11期

关键词：

Melanoma; Mediastinal germ cell tumor; Teratoma; Molecular analysis; KIT; NRAS; KIT; COMPONENTS; TERATOMA;

D O I：

10.1016/j.prp.2020.153210

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histo-pathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

引用

页数：6

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