Synthesis and reactivity of high-molecular-mass phosphorylated poly(ethylene glycol)

被引：1
|
作者：
Pace, G
Veronese, FM
Bonora, GM
机构：
[1] Univ Trieste, Dept Chem Sci, I-34127 Trieste, Italy
[2] Univ Padua, Dept Pharmaceut Sci, Padua, Italy
来源：
REACTIVE & FUNCTIONAL POLYMERS | 1999年 / 41卷 / 1-3期
关键词：
poly(ethylenglycol); conjugate; phosphorylation; oligonucleotide; liquid-phase synthesis;
D O I：
10.1016/S1381-5148(99)00018-8
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
New phosphorylated monomethoxy poly(ethylene glycol)s (MPEGs) were obtained and used to prepare diMPEG-conjugated oligonucleotides. The chemical similarity with other organic molecules carrying diester bonds can be easily envisaged, allowing for further applications of these new MPEG units. Both high-molecular-mass phosphodiester- and phosphoramidite-derivatives have been obtained, characterized and evaluated for their reactivity. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：141 / 148
页数：8
相关论文
共 50 条
  • [41] Molecular design of heterotelechelic poly(ethylene glycol) for superbiomolecule
    Nagasaki, Y
    Kato, M
    Kataoka, K
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 26 - POLY
  • [42] Synthesis of poly(ethylene glycol)-based hydrogels and their swelling/shrinking response to molecular recognition
    Tominaga, Yuichi
    Kubo, Takuya
    Sueyoshi, Kenji
    Hosoya, Ken
    Otsuka, Koji
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2013, 51 (15) : 3153 - 3158
  • [43] Synthesis and characterization of poly(ethylene glycol) methyl ether endcapped poly(ethylene terephthalate)
    Lin, Q
    Unal, S
    Fornof, AR
    Wei, YP
    Li, HM
    Armentrout, RS
    Long, TE
    MACROMOLECULAR SYMPOSIA, 2003, 199 : 163 - 172
  • [44] Synthesis and Properties of Magnetite Nanoparticles Coated with Poly(ethylene glycol) and Poly(ethylene imine)
    Zhao, Fangyuan
    Zhang, Baolin
    Wang, Jun
    Tu, Zhijiang
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2013, 13 (10) : 6793 - 6797
  • [45] RAPID DETECTION OF HIGH-MOLECULAR-MASS DIENES IN BEESWAX
    GIUMANINI, AG
    VERARDO, G
    STRAZZOLINI, P
    HEPBURN, HR
    JOURNAL OF CHROMATOGRAPHY A, 1995, 704 (01) : 224 - 227
  • [46] Thermal properties of poly(L-lactide)/poly(ethylene glycol) blends based on different poly (ethylene glycol) molecular weights
    Chiu, Fang-Chyou
    Kan, Chin-Yu
    Wu, Yung-Chien
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [47] The spherical stratification of discharge in high-molecular-mass gases
    Nerushev, OA
    Novopashin, SA
    Radchenko, VV
    Sukhinin, GI
    TECHNICAL PHYSICS LETTERS, 2001, 27 (02) : 118 - 120
  • [48] High-molecular-mass components of Vietnamese crude oils
    Golovko, AK
    Gorbunova, LV
    Kam'yanov, VF
    Dong, CL
    Savinykh, YV
    PETROLEUM CHEMISTRY, 2003, 43 (04) : 226 - 229
  • [49] Physiochemical properties of low and high molecular weight poly(ethylene glycol)-grafted poly(ethylene imine) copolymers and their complexes with oligonucleotides
    Glodde, M
    Sirsi, SR
    Lutz, GJ
    BIOMACROMOLECULES, 2006, 7 (01) : 347 - 356
  • [50] Synthesis and application of a new high-molecular-mass hydroxamic acid flocculant containing phenyl
    School of Sciences, Northeastern University, Shenyang 110004, China
    不详
    Zhongguo Youse Jinshu Xuebao, 2007, 3 (498-503):
12345