Synthesis and reactivity of high-molecular-mass phosphorylated poly(ethylene glycol)

被引：1
|
作者：
Pace, G
Veronese, FM
Bonora, GM
机构：
[1] Univ Trieste, Dept Chem Sci, I-34127 Trieste, Italy
[2] Univ Padua, Dept Pharmaceut Sci, Padua, Italy
来源：
REACTIVE & FUNCTIONAL POLYMERS | 1999年 / 41卷 / 1-3期
关键词：
poly(ethylenglycol); conjugate; phosphorylation; oligonucleotide; liquid-phase synthesis;
D O I：
10.1016/S1381-5148(99)00018-8
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
New phosphorylated monomethoxy poly(ethylene glycol)s (MPEGs) were obtained and used to prepare diMPEG-conjugated oligonucleotides. The chemical similarity with other organic molecules carrying diester bonds can be easily envisaged, allowing for further applications of these new MPEG units. Both high-molecular-mass phosphodiester- and phosphoramidite-derivatives have been obtained, characterized and evaluated for their reactivity. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：141 / 148
页数：8
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