The Role of HIV Infection, Cognition, and Depression in Risky Decision-Making

被引：31

作者：

Thames, April D. ^{[1
]}

Streiff, Vanessa ^{[1
]}

Patel, Sapna M. ^{[1
]}

Panos, Stella E. ^{[1
]}

Castellon, Steven A. ^{[1
]}

Hinkin, Charles H. ^{[1
]}

机构：

[1] UCLA Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2012年 / 24卷 / 03期

关键词：

GAMBLING TASK-PERFORMANCE; PREFRONTAL CORTEX; SUBSTANCE; REWARD; INDIVIDUALS; DISTURBANCE; PUNISHMENT; COMPONENTS; FEEDBACK; ANXIETY;

D O I：

10.1176/appi.neuropsych.11110340

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined the impact of HIV, cognitive dysfunction, and depression on decision-making. HIV+ (N=100) and HIV- (N=26) participants were administered a comprehensive neuropsychological battery, a modified version of the Iowa Gambling Task, and a measure of depressive symptoms. HIV+ participants demonstrated more difficulties in learning the gambling task than did HIV- participants. Executive functioning and depression emerged as strong predictors of gambling task performance. Depression partially mediated the relationship between executive functioning and gambling performance. Our findings suggest that HIV infection, executive dysfunction, and depression place individuals at risk for poor decision-making. (The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:340-348)

引用

页码：340 / 348

页数：9

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