Safety and Pharmacokinetics of a Novel Formulation of Human Apolipoprotein A-I (CSL112) in Healthy Subjects: Results of a Placebo-Controlled, Randomized Multiple Ascending Dose Study

被引：0
|
作者：
Easton, Rachael [1 ]
Tremper, Louise [2 ]
Shear, Charles [1 ]
机构：
[1] CSL Behring, King Of Prussia, PA USA
[2] CSL Ltd, Clin Study Management, Parkville, Vic, Australia
来源：
CIRCULATION | 2012年 / 126卷 / 21期
关键词：
Acute coronary syndromes; Apolipoproteins; HDL elevating therapies; Pharmacokinetics; Clinical trials;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
11892
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Pharmacokinetics, Safety, and Tolerability of Single- and Multiple-Dose Once-Daily Baricitinib in Healthy Chinese Subjects: A Randomized Placebo-Controlled Study
    Zhao, Xia
    Sheng, Xiao Yan
    Payne, Christopher D.
    Zhang, Xin
    Wang, Feng
    Cui, Yi Min
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2020, 9 (08): : 952 - 960
  • [42] A Randomized, Double-Blinded, Placebo-Controlled, Ascending Dose Study Of The Safety, Tolerability, And Pharmacokinetics Of ®Xmab 7195
    Gershman, A.
    Goldwater, R.
    Foster, P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [43] A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Intravenous and Subcutaneous Garadacimab (CSL312) in Healthy Subjects
    McKenzie, Andrew
    Roberts, Anthony
    Malandkar, Sourabh
    Feuersenger, Henrike
    Panousis, Con
    Pawaskar, Dipti
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (02) : AB137 - AB137
  • [44] A Phase I, Randomized, Observer-Blinded, Placebo-Controlled, Single and Multiple Ascending-Dose Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of BITS7201A in Healthy Volunteers
    Chen, H.
    Peng, K.
    Choy, D. F.
    Cabanski, C.
    Fong, A.
    Brunstein, F.
    Rajapaksa, K.
    Templeton, I.
    Staton, T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [45] A randomized, controlled single, and multiple ascending dose trial of the safety, pharmacokinetics and pharmacodynamics of SN1011 in healthy subjects
    Zhu, Leilei
    Shi, Rong
    Zhao, Tongfang
    Ye, Yujie
    Tang, Jie
    Hu, Yihui
    Peng, Peng
    Wang, Dong
    Chong, Clement
    Xu, Guolin
    Leung, Shui-on
    Yuan, Wei'an
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2023, 16 (10): : 1982 - 1996
  • [46] Safety, Tolerability and Pharmacokinetics of Dalcetrapib Following Single and Multiple Ascending Doses in Healthy SubjectsA Randomized, Double-Blind, Placebo-Controlled, Phase I Study
    Michael Derks
    Judith Anzures-Cabrera
    Lynn Turnbull
    Mary Phelan
    Clinical Drug Investigation, 2011, 31 : 325 - 335
  • [47] A Randomized, Double-Blind, Placebo-Controlled, Single-Centre, Single Ascending Dose And Multiple Ascending Dose Study Of The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Molgramostim (rhgm-Csf) Administered By Inhalation To Healthy Adult Subjects
    Tarnow, I.
    Nymark, K.
    Vinge, M.
    Nielsen, K. A.
    Ganslandt, C.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [48] An ascending multiple-dose study of the safety and pharmacokinetics of a sustained-release formulation of desvenlafaxine succinate in healthy subjects
    Richards, LS
    Behrle, JA
    Nichols, AI
    Fruncillo, RJ
    Paul, J
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (02) : P84 - P84
  • [49] Safety and tolerance of methylnaltrexone in healthy humans: A randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study
    Foss, JF
    OConnor, M
    Yuan, CS
    Murphy, M
    Moss, J
    Roizen, MF
    JOURNAL OF CLINICAL PHARMACOLOGY, 1997, 37 (01): : 25 - 30
  • [50] Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo-Controlled, Multiple-Dose Study
    Yu, Brian
    Adedoyin, Adedayo
    Hershberger, Ellie
    Caro, Luzelena
    Xiao, Alan
    Rhee, Elizabeth G.
    Huntington, Jennifer A.
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2018, 7 (04): : 382 - 391
12345