Safety and Pharmacokinetics of a Novel Formulation of Human Apolipoprotein A-I (CSL112) in Healthy Subjects: Results of a Placebo-Controlled, Randomized Multiple Ascending Dose Study

被引：0
|
作者：
Easton, Rachael [1 ]
Tremper, Louise [2 ]
Shear, Charles [1 ]
机构：
[1] CSL Behring, King Of Prussia, PA USA
[2] CSL Ltd, Clin Study Management, Parkville, Vic, Australia
来源：
CIRCULATION | 2012年 / 126卷 / 21期
关键词：
Acute coronary syndromes; Apolipoproteins; HDL elevating therapies; Pharmacokinetics; Clinical trials;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
11892
引用
收藏
页数：2
相关论文
共 50 条
  • [31] A placebo-controlled, randomized, single and multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of rimegepant in healthy participants
    Bertz, Richard
    Bhardwaj, Rajinder
    Morris, Beth A. A.
    Ashbrenner, Eric
    Coric, Vladimir
    Croop, Robert
    CEPHALALGIA, 2023, 43 (06)
  • [32] Safety and pharmacokinetics of the nonnucleoside polymerase inhibitor, HCV-796: Results of a randomized, double-blind, placebo-controlled, ascending single-dose study in healthy subjects
    Chandra, P.
    Raible, D.
    Moyer, L.
    Harper, D.
    Speth, J.
    Villano, S.
    Fruncillo, R.
    JOURNAL OF HEPATOLOGY, 2006, 44 : S208 - S209
  • [33] A Double-blind, Placebo-controlled, Randomized, Single Ascending, and Multiple Dose Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral Dose Isomyosamine Capsules in Healthy Adult Subjects
    Brager, Jenna
    Chapman, Chris
    Dunn, Leonard
    Kaplin, Adam
    DRUG RESEARCH, 2023, 73 (02) : 95 - 104
  • [34] A RANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY AND PHARMACOKINETICS OF OCR-002 IN HEALTHY VOLUNTEERS
    Jochelson, P.
    van de Wetering, J. L.
    Bornstein, J.
    Resler, M.
    Anderson, K.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S70 - S70
  • [35] Correction to: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
    Lesley Taylor
    Barry Gidal
    Graham Blakey
    Bola Tayo
    Gilmour Morrison
    CNS Drugs, 2019, 33 : 397 - 397
  • [36] A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX-02 in Healthy Subjects
    Leubitz, Andi
    Vanhoutte, Frederic
    Hu, Ming-yi
    Porter, Kaela
    Gordon, Efrat
    Tencer, Kathleen
    Campbell, Kathleen
    Banks, Kate
    Haverty, Tom
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (08): : 859 - 869
  • [37] Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study
    Risinger, Robert
    Bhagwagar, Zubin
    Luo, Feng
    Cahir, Matthew
    Miler, Laura
    Mendonza, Anisha E.
    Meyer, Jeffrey H.
    Zheng, Ming
    Hayes, Wendy
    PSYCHOPHARMACOLOGY, 2014, 231 (11) : 2299 - 2310
  • [38] Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study
    Robert Risinger
    Zubin Bhagwagar
    Feng Luo
    Matthew Cahir
    Laura Miler
    Anisha E. Mendonza
    Jeffrey H. Meyer
    Ming Zheng
    Wendy Hayes
    Psychopharmacology, 2014, 231 : 2299 - 2310
  • [39] Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study
    Li, Lijun
    Gao, Hongzhi
    Lou, Kun
    Luo, Hongmei
    Hao, Sheng
    Yuan, Jing
    Liu, Zeyuan
    Dong, Ruihua
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021, 14 (05): : 2017 - 2024
  • [40] First-in-human safety, tolerability, and pharmacokinetics of ammoxetine in healthy subjects: a randomized, double-blind, placebo-controlled phase I study
    Shen, Qi
    Hu, Chao
    Miao, Jia
    Chen, Junxia
    Peng, Yueying
    Pan, Tingting
    He, Xiaolin
    Yuan, Jing
    Ni, Shaonan
    Wang, Yongsheng
    Luo, Zhu
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 159
12345