Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia

被引：71
|
作者：
Matosin, Natalie [1 ,2 ]
Newell, Kelly A. [1 ,2 ]
机构：
[1] Univ Wollongong, Sch Hlth Sci, Ctr Translat Neurosci, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
[2] Schizophrenia Res Inst, Sydney, NSW 2010, Australia
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2013年 / 37卷 / 03期
关键词：
mGluR5; mGlu5; Metabotropic glutamate receptor 5; Schizophrenia; NMDA receptor; Positive allosteric modulator; PAM; Antipsychotic; POSITIVE ALLOSTERIC MODULATOR; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; MESSENGER-RNA EXPRESSION; AMINO-ACID TRANSPORTER-2; RAT BEHAVIORAL-MODELS; IN-VIVO ACTIVITY; NMDA-RECEPTOR; PREFRONTAL CORTEX; PREPULSE INHIBITION;
D O I：
10.1016/j.neubiorev.2012.12.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Metabotropic glutamate receptor 5 (mGluR5) potentiates the NMDA receptor (NMDAR) in brain regions implicated in schizophrenia, making it a viable therapeutic target for the treatment of this disorder. mGluR5 positive allosteric modulators may represent a valuable novel strategy for schizophrenia treatment, given the favourable profile of effects in preclinical paradigms. However it remains unclear whether mGluR5 also plays a causal or epiphenomenal role in NMDAR dysfunction in schizophrenia. Animal and cellular data suggest involvement of mGluR5, whilst post-mortem human studies remain inconclusive. This review will explore the molecular, animal and human data to support and refute the involvement of mGluR5 in the pathology of schizophrenia. Furthermore, this review will discuss the potential of mGluR5 modulators in the therapy of schizophrenia as well as aspects of mGluR5 that require further characterisation. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：256 / 268
页数：13
相关论文
共 50 条
  • [41] Reduced Metabotropic Glutamate Receptor 5 in Major Depression
    Deschwanden, Alexandra
    Karolewicz, Beata
    Feyissa, Anteneh
    Treyer, Valerie
    Ametamey, Simon M.
    Johayem, Anass
    Auberson, Yves
    Sovago, Judit
    Stockmeier, Craig A.
    Buck, Alfred
    Hasler, Gregor
    [J]. BIOLOGICAL PSYCHIATRY, 2010, 67 (09) : 190S - 190S
  • [42] Metabotropic Glutamate Receptor Type 5 in Human Glioma
    Nickols, Hilary
    Rook, Jerri
    Byun, Nellie
    Conn, P.
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (06): : 569 - 569
  • [43] Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    Gupta, DS
    McCullumsmith, RE
    Beneyto, M
    Haroutunian, V
    Davis, KL
    Meador-Woodruff, JH
    [J]. SYNAPSE, 2005, 57 (03) : 123 - 131
  • [44] Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia
    Chaki, Shigeyuki
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 639 (1-3) : 59 - 66
  • [45] ALTERED EXPRESSION OF METABOTROPIC GLUTAMATE RECEPTOR PROTEINS IN FRONTOSTRIATAL REGIONS IN SCHIZOPHRENIA
    Ghose, Subroto
    Gleason, Kelly
    Shukla, Abhay
    [J]. SCHIZOPHRENIA BULLETIN, 2011, 37 : 190 - 190
  • [46] Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety
    Raber, Jacob
    Duvoisin, Robert M.
    [J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2015, 24 (04) : 519 - 528
  • [47] Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5
    Burrows, Emma L.
    McOmish, Caitlin E.
    Buret, Laetitia S.
    Van den Buuse, Maarten
    Hannan, Anthony J.
    [J]. NEUROPSYCHOPHARMACOLOGY, 2015, 40 (08) : 1947 - 1956
  • [48] Microbiome Profiling Reveals Gut Dysbiosis in the Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Schizophrenia
    Gubert, Carolina
    Kong, Geraldine
    Uzungil, Volkan
    Zeleznikow-Johnston, Ariel M.
    Burrows, Emma L.
    Renoir, Thibault
    Hannan, Anthony J.
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [49] Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5
    Emma L Burrows
    Caitlin E McOmish
    Laetitia S Buret
    Maarten Van den Buuse
    Anthony J Hannan
    [J]. Neuropsychopharmacology, 2015, 40 : 1947 - 1956
  • [50] Metabotropic glutamate receptor 5 signaling and appetitive Pavlovian behavior: implications for the treatment of addiction
    Richard, Jocelyn M.
    [J]. NEUROPSYCHOPHARMACOLOGY, 2019, 44 (09) : 1516 - 1517
12345