Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia

被引：71
|
作者：
Matosin, Natalie [1 ,2 ]
Newell, Kelly A. [1 ,2 ]
机构：
[1] Univ Wollongong, Sch Hlth Sci, Ctr Translat Neurosci, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
[2] Schizophrenia Res Inst, Sydney, NSW 2010, Australia
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2013年 / 37卷 / 03期
关键词：
mGluR5; mGlu5; Metabotropic glutamate receptor 5; Schizophrenia; NMDA receptor; Positive allosteric modulator; PAM; Antipsychotic; POSITIVE ALLOSTERIC MODULATOR; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; MESSENGER-RNA EXPRESSION; AMINO-ACID TRANSPORTER-2; RAT BEHAVIORAL-MODELS; IN-VIVO ACTIVITY; NMDA-RECEPTOR; PREFRONTAL CORTEX; PREPULSE INHIBITION;
D O I：
10.1016/j.neubiorev.2012.12.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Metabotropic glutamate receptor 5 (mGluR5) potentiates the NMDA receptor (NMDAR) in brain regions implicated in schizophrenia, making it a viable therapeutic target for the treatment of this disorder. mGluR5 positive allosteric modulators may represent a valuable novel strategy for schizophrenia treatment, given the favourable profile of effects in preclinical paradigms. However it remains unclear whether mGluR5 also plays a causal or epiphenomenal role in NMDAR dysfunction in schizophrenia. Animal and cellular data suggest involvement of mGluR5, whilst post-mortem human studies remain inconclusive. This review will explore the molecular, animal and human data to support and refute the involvement of mGluR5 in the pathology of schizophrenia. Furthermore, this review will discuss the potential of mGluR5 modulators in the therapy of schizophrenia as well as aspects of mGluR5 that require further characterisation. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：256 / 268
页数：13
相关论文
共 50 条
  • [31] Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
    Conn, P. Jeffrey
    Lindsley, Craig W.
    Jones, Carrie K.
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (01) : 25 - 31
  • [32] Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia
    Bita Moghaddam
    [J]. Psychopharmacology, 2004, 174 : 39 - 44
  • [33] Circadian pattern of the metabotropic glutamate receptor 5 in the rat
    Elmenhorst, D.
    Mertens, K.
    Kroll, T.
    Oskamp, A.
    Ermert, J.
    Elmenhorst, E. -M.
    Wedekind, F.
    Beer, S.
    Coenen, H. H.
    Bauer, A.
    [J]. JOURNAL OF SLEEP RESEARCH, 2016, 25 : 199 - 200
  • [34] Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia
    Moghaddam, B
    [J]. PSYCHOPHARMACOLOGY, 2004, 174 (01) : 39 - 44
  • [35] Metabotropic glutamate receptor 5: a target for migraine therapy
    Waung, Maggie W.
    Akerman, Simon
    Wakefield, Mark
    Keywood, Charlotte
    Goadsby, Peter J.
    [J]. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2016, 3 (08): : 560 - 571
  • [36] New directions in the drug treatment of schizophrenia: metabotropic glutamate receptors
    Schoepp, D.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 : S179 - S179
  • [37] Metabotropic Glutamate Receptors: Potential Drug Targets for the Treatment of Schizophrenia
    Chavez-Noriega, Laura E.
    Schaffhauser, Herve
    Campbell, Una C.
    [J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2002, 1 (03) : 261 - 281
  • [38] Involvement of metabotropic glutamate 5 receptor in visceral pain
    Lindstrom, Erik
    Brusberg, Mikael
    Hughes, Patrick A.
    Martin, Christopher M.
    Brierley, Stuart M.
    Phillis, Benjamin D.
    Martinsson, Rakel
    Abrahamsson, Christina
    Larsson, Hakan
    Martinez, Vicente
    Blackshaw, L. Ashley
    [J]. PAIN, 2008, 137 (02) : 295 - 305
  • [39] Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome
    Lancaster, E.
    Martinez-Hernandez, E.
    Titulaer, M. J.
    Boulos, M.
    Weaver, S.
    Antoine, J. -C.
    Liebers, E.
    Kornblum, C.
    Bien, C. G.
    Honnorat, J.
    Wong, S.
    Xu, J.
    Contractor, A.
    Balice-Gordon, R.
    Dalmau, J.
    [J]. NEUROLOGY, 2011, 77 (18) : 1698 - 1701
  • [40] The role of the metabotropic glutamate receptor 5 in nicotine addiction
    Akkus, Funda
    Terbeck, Sylvia
    Haggarty, Connor J.
    Treyer, Valerie
    Dietrich, Janan J.
    Hornschuh, Stefanie
    Hasler, Gregor
    [J]. CNS SPECTRUMS, 2021, 26 (06) : 601 - 606
12345